Fig. 2.   Overview of the complex actions of IL-2 family members in the vascular wall. All members are produced by cellular constituents of the atherosclerotic plaque (dotted line: EC, endothelial cell; SMC, smooth muscle cell; M, macrophage; TC, T cell) and exert effects that are considered to be either pro-atherogenic (continuous line) or anti-atherogenic (dashed line).