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Pharmacological Reviews, Vol 11, 307-316, Copyright © 1959 by the American Society for Pharmacology and Experimental Therapeutics

THE DEVELOPMENT OF CURRENT CONCEPTS OF CATECHOLAMINE FORMATION

H. Blaschko 1

1 Department of Pharmacology, Oxford University, England

We can today, with a fair degree of certainty, describe the main stages in the formation of the catecholamines. But many problems remain, e.g., that of the intimate nature of some of the intermediate chemical reactions and also that of the spatial relationship of the various stages and their correlation in the living cell. It must remain for the future to discover the nature of the intracellular signalling system, by which the storage site is told that amine is to be released, and also to study what we might call the "adequate stimulus" for re-synthesis.






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