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Pharmacological Reviews, Vol 27, 307-323, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Characteristics of Behavior Controlled by Scheduled Injections of Drugs

R. T. Kelleher 1

1 Laboratory of Psychobiology, Department of Psychiatry, Harvard Medical School, Boston and New England Regional Primate Research Center, Southborough, Massachusetts

It has been well established that the injections of various classes of drugs can reinforce behavior in experimental animals; however, there is a need to characterize the properties of drugs as reinforcers. The maintenance of behavior by self-administration of drugs is determined by various conditions in addition to the direct effects of the drug itself. The present paper has emphasized the importance of the schedule of drug injections in determining how drugs function as reinforcers. In this context, it was shown that certain secondorder schedules provide a technique for establishing powerful control over behavior with drugs as diverse as cocaine, methohexital, and morphine.






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