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Pharmacological Reviews, Vol 27, 511-521, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Drugs as Reinforcers in Monkey and Man

Charles R. Schuster 1

1 Departments of Psychiatry and Pharmacological and Physiological Sciences, Pritzker School of Medicine, The University of Chicago, Chicago, Illinois

I have presented data to illustrate and evaluate the use of animal experiments on behavior maintained by drug injection as an animal model of human drug abuse. I believe, the data justify the cautious application of such an animal model for predicting the abuse potential of a new drug, for evaluating new forms of treatment, and finally, for investigating biological and environmental variables controlling drug taking behavior. However, there are a variety of assumptions whenever we extrapolate conclusions from laboratory studies to man in his natural environment.






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