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Pharmacological Reviews, Vol 4, 168-218, Copyright © 1952 by the American Society for Pharmacology and Experimental Therapeutics

NEUROPHARMACOLOGY OF PERIPHERAL NERVE

JAMES E. P. TOMAN 1

1 Institute for Psychosomatic and Psychiatric Research and Training, Michael Reese Hospital, Chicago, Illinois

1. Some basic properties of peripheral nerve are discussed, together with notes their measurement and on some typical effects of drugs.

2. The actions of a variety of drugs on peripheral nerve are described.

3. A suggested empirical scheme is presented for the tentative classification drugs acting on peripheral nerve.

4. Interrelationships between drugs in several categories of mechanism of action discussed, with particular attention to the contradictory actions of presumed chemical mediators and blocking agents.

5. The applicability of modern peripheral nerve methodology to brain neuropharmacology is noted.

6. Some speculations are presented on the continuity between "resting" and "active" functions in nerve.






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