| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 49, Issue 2, 143-156, June 1997
Division of Pharmacology (H.E.d.V., A.G.d.B., D.D.B.) and
Division
of Biopharmaceutics (H.E.d.V., J.K., T.J.C.V.B.), Leiden/Amsterdam
Center for Drug Research, University of Leiden, The Netherlands
I. The Blood-Brain Barrier
A. Morphology and Function
B. Mechanisms of Transport of Compounds Across the Blood-Brain
Barrier
II. Pathophysiology of the Blood-Brain Barrier in Neurological
Diseases
A. Inflammatory Mediators during Neurological Diseases
1. Cytokines.
2. Eicosanoids.
3. Free radicals.
4. Adhesion molecules.
B. Neurological Diseases Affecting the Blood-Brain Barrier
1. Multiple sclerosis and experimental allergic
encephalomyelitis.
2. Bacterial meningitis.
3. Ischemia.
4. Brain edema.
5. Alzheimer's disease.
6. Acquired immune deficiency syndrome dementia complex.
III. Final Considerations
References
This article has been cited by other articles:
|
|
 |
|
  E. T. Morgan, K. B. Goralski, M. Piquette-Miller, K. W. Renton, G. R. Robertson, M. R. Chaluvadi, K. A. Charles, S. J. Clarke, M. Kacevska, C. Liddle, et al. Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer Drug Metab. Dispos., February 1, 2008; 36(2): 205 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zeni, E. Doepker, U. S. Topphoff, S. Huewel, T. Tenenbaum, and H.-J. Galla MMPs contribute to TNF-{alpha}-induced alteration of the blood-cerebrospinal fluid barrier in vitro Am J Physiol Cell Physiol, September 1, 2007; 293(3): C855 - C864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Soon, D. Tozer, D. Altmann, P. Tofts, and D. Miller Quantification of subtle blood-brain barrier disruption in non-enhancing lesions in multiple sclerosis: a study of disease and lesion subtypes Multiple Sclerosis, August 1, 2007; 13(7): 884 - 894. [Abstract] [PDF]
|
|
|
|
 |
|
 D. S. Streetman Clinical Pharmacogenetics of the Major Adenosine Triphosphate Binding Cassette and Solute Carrier Drug Transporters Journal of Pharmacy Practice, June 1, 2007; 20(3): 219 - 233. [Abstract] [PDF]
|
|
|
|
 |
|
 R. D. Oude Engberink, S. M. A. van der Pol, E. A. Dopp, H. E. de Vries, and E. L. A. Blezer Comparison of SPIO and USPIO for in Vitro Labeling of Human Monocytes: MR Detection and Cell Function Radiology, May 1, 2007; 243(2): 467 - 474. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Fabis, G. S. Scott, R. B. Kean, H. Koprowski, and D. C. Hooper Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models PNAS, March 27, 2007; 104(13): 5656 - 5661. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kohelet, R. Shochat, A. Lusky, and B. Reichman Risk Factors for Seizures in Very Low Birthweight Infants With Periventricular Leukomalacia J Child Neurol, November 1, 2006; 21(11): 965 - 970. [Abstract] [PDF]
|
|
|
|
 |
|
 L. Sunday, M. M. Tran, D. N. Krause, and S. P. Duckles Estrogen and progestagens differentially modulate vascular proinflammatory factors Am J Physiol Endocrinol Metab, August 1, 2006; 291(2): E261 - E267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Phares, R. B. Kean, T. Mikheeva, and D. C. Hooper Regional differences in blood-brain barrier permeability changes and inflammation in the apathogenic clearance of virus from the central nervous system. J. Immunol., June 15, 2006; 176(12): 7666 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Scott, R. B. Kean, T. Mikheeva, M. J. Fabis, J. G. Mabley, C. Szabo, and D. C. Hooper The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation J. Pharmacol. Exp. Ther., September 1, 2004; 310(3): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Ospina, H. N. Brevig, D. N. Krause, and S. P. Duckles Estrogen suppresses IL-1{beta}-mediated induction of COX-2 pathway in rat cerebral blood vessels Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H2010 - H2019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Song, C. Pope, R. Murthy, J. Shaikh, B. Lal, and J. P. Bressler Interactive Effects of Paraoxon and Pyridostigmine on Blood-Brain Barrier Integrity and Cholinergic Toxicity Toxicol. Sci., April 1, 2004; 78(2): 241 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Floris, E. L. A. Blezer, G. Schreibelt, E. Dopp, S. M. A. van der Pol, I. L. Schadee-Eestermans, K. Nicolay, C. D. Dijkstra, and H. E. de Vries Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: A quantitative MRI study Brain, March 1, 2004; 127(3): 616 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. V. Kim, F. Di Cello, C. S. Hillaire, and K. S. Kim Differential Ca2+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells Am J Physiol Cell Physiol, January 1, 2004; 286(1): C31 - C42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Minagar and J S. Alexander Blood-brain barrier disruption in multiple sclerosis Multiple Sclerosis, December 1, 2003; 9(6): 540 - 549. [Abstract] [PDF]
|
|
|
|
 |
|
 N J Abbott, L L. Mendonca, and D E. Dolman The blood-brain barrier in systemic lupus erythematosus Lupus, December 1, 2003; 12(12): 908 - 915. [Abstract] [PDF]
|
|
|
|
 |
|
 H. K. Avraham, T.-H. Lee, Y. Koh, T.-A. Kim, S. Jiang, M. Sussman, A. M. Samarel, and S. Avraham Vascular Endothelial Growth Factor Regulates Focal Adhesion Assembly in Human Brain Microvascular Endothelial Cells through Activation of the Focal Adhesion Kinase and Related Adhesion Focal Tyrosine Kinase J. Biol. Chem., September 19, 2003; 278(38): 36661 - 36668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. ABREU-SILVA, K. S. CALABRESE, R. C. TEDESCO, R. A. MORTARA, and S. C. G. DA COSTA CENTRAL NERVOUS SYSTEM INVOLVEMENT IN EXPERIMENTAL INFECTION WITH LEISHMANIA (LEISHMANIA) AMAZONENSIS Am J Trop Med Hyg, June 1, 2003; 68(6): 661 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Pfister, L. Zhang, M. Hammarlund-Udenaes, L. B. Sheiner, C. M. Gerber, M. G. Tauber, and P. Cottagnoud Modeling of Transfer Kinetics at the Serum-Cerebrospinal Fluid Barrier in Rabbits with Experimental Meningitis: Application to Grepafloxacin Antimicrob. Agents Chemother., January 1, 2003; 47(1): 138 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. K. Boje, D. Jaworowicz Jr., and J. J. Raybon Neuroinflammatory Role of Prostaglandins during Experimental Meningitis: Evidence Suggestive of an in Vivo Relationship between Nitric Oxide and Prostaglandins J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 319 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Esposito, N. Chandler, K. Kandere, S. Basu, S. Jacobson, R. Connolly, D. Tutor, and T. C. Theoharides Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1061 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Lee, D. G. Na, K. H. Choi, K. J. Kim, J. W. Ryoo, S. Y. Lee, and Y.-L. Suh Subcortical Low Intensity on MR Images of Meningitis, Viral Encephalitis, and Leptomeningeal Metastasis AJNR Am. J. Neuroradiol., April 1, 2002; 23(4): 535 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Schrijver, M. van Meurs, M.-J. Melief, C. Wim Ang, D. Buljevac, R. Ravid, M. P. Hazenberg, and J. D. Laman Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis Brain, August 1, 2001; 124(8): 1544 - 1554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. FRIGERI, G. P. NICCHIA, B. NICO, F. QUONDAMATTEO, R. HERKEN, L. RONCALI, and M. SVELTO Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice FASEB J, January 1, 2001; 15(1): 90 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. K. Boje and S. S. Lakhman Nitric Oxide Redox Species Exert Differential Permeability Effects on the Blood-Brain Barrier J. Pharmacol. Exp. Ther., May 1, 2000; 293(2): 545 - 550. [Abstract] [Full Text]
|
|
|
|
|
|
L. Tsenova, A. Bergtold, V. H. Freedman, R. A. Young, and G. Kaplan Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system PNAS, May 11, 1999; 96(10): 5657 - 5662. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
 |
 |
 |
|
 |
 |
 |
