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Vol. 49, Issue 2, 143-156, June 1997

The Blood-Brain Barrier in Neuroinflammatory Diseases

Helga E. de Vriesa , Johan Kuiper, Albertus G. de Boer, Theo J. C. Van Berkel and Douwe D. Breimer

Division of Pharmacology (H.E.d.V., A.G.d.B., D.D.B.) and Division of Biopharmaceutics (H.E.d.V., J.K., T.J.C.V.B.), Leiden/Amsterdam Center for Drug Research, University of Leiden, The Netherlands

I. The Blood-Brain Barrier
    A. Morphology and Function
    B. Mechanisms of Transport of Compounds Across the Blood-Brain Barrier
II. Pathophysiology of the Blood-Brain Barrier in Neurological Diseases
    A. Inflammatory Mediators during Neurological Diseases
        1. Cytokines.
        2. Eicosanoids.
        3. Free radicals.
        4. Adhesion molecules.
    B. Neurological Diseases Affecting the Blood-Brain Barrier
        1. Multiple sclerosis and experimental allergic encephalomyelitis.
        2. Bacterial meningitis.
        3. Ischemia.
        4. Brain edema.
        5. Alzheimer's disease.
        6. Acquired immune deficiency syndrome dementia complex.
III. Final Considerations
References

a   Address correspondence to: H. E. de Vries, Division of Biopharmaceutics, Wassenaarseweg 72, P.O. Box 9503, 2300 RA Leiden, The Netherlands.

0031-6997/97/4902-0143$03.00/0
PHARMACOLOGICAL REVIEWS
Copyright © 1997 by The American Society for Pharmacology and Experimental Therapeutics


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