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Vol. 49, Issue 3, 253-278, September 1997
Department of Physiology and Pharmacology (S.J.H.), Medical School,
Queen's Medical Centre, Nottingham, England;
Department of Chemistry
(C.R.G.), University College London, Christopher Ingold Laboratories,
London, England;
Department of Pharmacochemistry (H.T.),
Leiden/Amsterdam Center for Drug Research, Vrije Universiteit,
Amsterdam, The Netherlands;
Unité de Neurobiologie (J.C.S.),
Paris, France;
James Black Foundation (N.P.S.), King's College School
of Medicine and Dentistry, Dulwich, London, England;
Department of
Pharmacology (J.M.Y), University of Cambridge, Cambridge;
Freie
Universität Berlin (W.S.), Institut für Pharmazie I, Berlin
(Dahlem), Germany;
Department of Pharmacology (R.L.), Cornell
University Medical College, New York;
Department of Physiology
(H.L.H.), Heinrich Heine University, Düsseldorf, Germany
I. Introduction and Historical Perspective
II. Histamine H1-Receptor
A. Distribution and Function
B. H1-Selective Ligands
C. Receptor Structure
D. Signal Transduction Mechanisms
III. Histamine H2-Receptor
A. Distribution and Function
B. H2-Selective Ligands
C. Receptor Structure
D. Signal Transduction Mechanisms
IV. Histamine H3-Receptor
A. Distribution and Function
B. H3-Receptor Selective
Ligands
C. Receptor Structure
D. Signal Transduction Mechanisms
V. Other Responses to Histamine
A. Potentiation of Responses to N-Methyl-D-Aspartate
B. A Role as an Intracellular Messenger?
References
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T. W. Lovenberg, J. Pyati, H. Chang, S. J. Wilson, and M. G. Erlander Cloning of Rat Histamine H3 Receptor Reveals Distinct Species Pharmacological Profiles J. Pharmacol. Exp. Ther., June 1, 2000; 293(3): 771 - 778. [Abstract] [Full Text]
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K. P. M. Currie and A. P. Fox Voltage-Dependent, Pertussis Toxin Insensitive Inhibition of Calcium Currents by Histamine in Bovine Adrenal Chromaffin Cells J Neurophysiol, March 1, 2000; 83(3): 1435 - 1442. [Abstract] [Full Text] [PDF]
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R. Levi and N. C. E. Smith Histamine H3-Receptors: A New Frontier in Myocardial Ischemia J. Pharmacol. Exp. Ther., March 1, 2000; 292(3): 825 - 830. [Abstract] [Full Text]
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M. A. Giembycz and M. A. Lindsay Pharmacology of the Eosinophil Pharmacol. Rev., June 1, 1999; 51(2): 213 - 340. [Abstract] [Full Text] [PDF]
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T. W. Lovenberg, B. L. Roland, S. J. Wilson, X. Jiang, J. Pyati, A. Huvar, M. R. Jackson, and M. G. Erlander ACCELERATED COMMUNICATION: Cloning and Functional Expression of the Human Histamine H3 Receptor Mol. Pharmacol., June 1, 1999; 55(6): 1101 - 1107. [Abstract] [Full Text]
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X. Ligneau, J.-S. Lin, G. Vanni-Mercier, M. Jouvet, J. L. Muir, C. R. Ganellin, H. Stark, S. Elz, W. Schunack, and J.-C. Schwartz Neurochemical and Behavioral Effects of Ciproxifan, A Potent Histamine H3-Receptor Antagonist J. Pharmacol. Exp. Ther., November 1, 1998; 287(2): 658 - 666. [Abstract] [Full Text]
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 G. Gentilini, B.R. Curtis, and R.H. Aster An Antibody From a Patient With Ranitidine-Induced Thrombocytopenia Recognizes a Site on Glycoprotein IX That Is a Favored Target for Drug-Induced Antibodies Blood, October 1, 1998; 92(7): 2359 - 2365. [Abstract] [Full Text] [PDF]
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E. Hatta, K. Yasuda, and R. Levi Activation of Histamine H3 Receptors Inhibits Carrier-Mediated Norepinephrine Release in a Human Model of Protracted Myocardial Ischemia, J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 494 - 500. [Abstract] [Full Text]
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T. Oda, N. Morikawa, Y. Saito, Y. Masuho, and S.-i. Matsumoto Molecular Cloning and Characterization of a Novel Type of Histamine Receptor Preferentially Expressed in Leukocytes J. Biol. Chem., November 17, 2000; 275(47): 36781 - 36786. [Abstract] [Full Text] [PDF]
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M. Eto, T. Kitazawa, M. Yazawa, H. Mukai, Y. Ono, and D. L. Brautigan Histamine-induced Vasoconstriction Involves Phosphorylation of a Specific Inhibitor Protein for Myosin Phosphatase by Protein Kinase C alpha and delta Isoforms J. Biol. Chem., July 27, 2001; 276(31): 29072 - 29078. [Abstract] [Full Text] [PDF]
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R. B. Silver, C. J. Mackins, N. C. E. Smith, I. L. Koritchneva, K. Lefkowitz, T. W. Lovenberg, and R. Levi Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: A novel protective mechanism in myocardial ischemia PNAS, February 27, 2001; 98(5): 2855 - 2859. [Abstract] [Full Text] [PDF]
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