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Vol. 49, Issue 3, 253-278, September 1997

International Union of Pharmacology. XIII. Classification of Histamine Receptors

S. J. Hilla , C. R. Ganellin, H. Timmerman, J. C. Schwartz, N. P. Shankley, J. M. Young, W. Schunack, R. Levi and H. L. Haas

Department of Physiology and Pharmacology (S.J.H.), Medical School, Queen's Medical Centre, Nottingham, England; Department of Chemistry (C.R.G.), University College London, Christopher Ingold Laboratories, London, England; Department of Pharmacochemistry (H.T.), Leiden/Amsterdam Center for Drug Research, Vrije Universiteit, Amsterdam, The Netherlands; Unité de Neurobiologie (J.C.S.), Paris, France; James Black Foundation (N.P.S.), King's College School of Medicine and Dentistry, Dulwich, London, England; Department of Pharmacology (J.M.Y), University of Cambridge, Cambridge; Freie Universität Berlin (W.S.), Institut für Pharmazie I, Berlin (Dahlem), Germany; Department of Pharmacology (R.L.), Cornell University Medical College, New York; Department of Physiology (H.L.H.), Heinrich Heine University, Düsseldorf, Germany

I. Introduction and Historical Perspective
II. Histamine H1-Receptor
    A. Distribution and Function
    B. H1-Selective Ligands
    C. Receptor Structure
    D. Signal Transduction Mechanisms
III. Histamine H2-Receptor
    A. Distribution and Function
    B. H2-Selective Ligands
    C. Receptor Structure
    D. Signal Transduction Mechanisms
IV. Histamine H3-Receptor
    A. Distribution and Function
    B. H3-Receptor Selective Ligands
    C. Receptor Structure
    D. Signal Transduction Mechanisms
V. Other Responses to Histamine
    A. Potentiation of Responses to N-Methyl-D-Aspartate
    B. A Role as an Intracellular Messenger?
References

a   Address for correspondence: Professor S. J. Hill, Department of Physiology & Pharmacology, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom.

0031-6997/97/4903-0253$03.00/0
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Copyright © 1997 by The American Society for Pharmacology and Experimental Therapeutics


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[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

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Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
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[Abstract] [Full Text] [PDF]

Home page
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J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 1212 - 1221.
[Abstract] [Full Text] [PDF]

Home page
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Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 758 - 763.
[Abstract] [Full Text] [PDF]

Home page
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N. Fernandez, F. Monczor, B. Lemos, C. Notcovich, A. Baldi, C. Davio, and C. Shayo
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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H. Toyota, C. Dugovic, M. Koehl, A. D. Laposky, C. Weber, K. Ngo, Y. Wu, D. H. Lee, K. Yanai, E. Sakurai, et al.
Behavioral Characterization of Mice Lacking Histamine H3 Receptors
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[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
A. J. Uveges, D. Kowal, Y. Zhang, T. B. Spangler, J. Dunlop, S. Semus, and P. G. Jones
The Role of Transmembrane Helix 5 in Agonist Binding to the Human H3 Receptor
J. Pharmacol. Exp. Ther., May 1, 2002; 301(2): 451 - 458.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
H. K. Takahashi, A. Yoshida, H. Iwagaki, T. Yoshino, H. Itoh, T. Morichika, M. Yokoyama, T. Akagi, N. Tanaka, S. Mori, et al.
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J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 1013 - 1020.
[Abstract] [Full Text] [PDF]

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Home page
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Home page
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[Abstract] [Full Text]

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