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Vol. 49, Issue 4, 381-402, December 1997

Adenosine A2B Receptors

Igor Feoktistov and Italo Biaggionia

Divisions of Clinical Pharmacology and Cardiology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee

I. Introduction
II. Classification of Adenosine Receptors
III. Molecular Characterization of A2B Receptors
IV. Pharmacology of A2B Receptors
V. Distribution of A2B Receptors
VI. Intracellular Pathways Regulated by A2B Receptors
VII. Physiological Functions of A2B Receptors
    A. Control of Vascular Tone
    B. Cardiac Myocyte Contractility
    C. Modulation of Neurosecretion and Neurotransmission
    D. Cell Growth and Gene Expression
    E. Regulation of Intestinal Tone and Secretion
    F. Adenosine and Asthma
    G. Adenosine Receptors and Mast Cells
VIII. A2B Receptors as Therapeutic Targets
IX. Concluding Remarks
Acknowledgments
References

a   Address for correspondence: Italo Biaggioni, Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232-2195.

0031-6997/97/4904-0381$03.00/0
PHARMACOLOGICAL REVIEWS
Copyright © 1997 by The American Society for Pharmacology and Experimental Therapeutics


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