|
|
||||||||
Vol. 50, Issue 1, 143-150, March 1998
Department of Medicine (M.C.M.), University of Essen, Essen,
Germany;
Department of Pharmacy (A.B-S.), ETH Zürich,
Zürich, Switzerland;
Department of Pharmacology (H.C.), UMDS,
Guy's and St. Thomas Medical School, London, United Kingdom;
Dr. Karl
Thomae GmbH (H.N.D.), Biberach, Germany;
Garvan Institute of Medical
Research (H.H.), St. Vincent Hospital, Darlinghurst, Australia;
Department of Medical Pharmacology (D.L.), Uppsala University
Biomedical Center, Uppsala, Sweden;
Department of Psychiatry (R.Q.),
Douglas Hospital Research Centre, McGill University, Verdun, Quebec,
Canada;
Laboratory of Molecular Endocrinology (T.S.), Rigshospitalet,
Copenhagen, Denmark;
Department of Pharmacology (T.W.), St. Louis
University, St. Louis, Missouri
I. Introduction
II. Signal Transduction of Neuropeptide Y Receptors
III. Historical Aspects of Neuropeptide Y Receptor Subdivision
IV. Present Definition of Neuropeptide Y Receptors
V. Characteristics of Receptor Subtypes (table
1)
A. Y1 Receptors
B. Y2 Receptors
C. Putative Y3 Receptors
D. Y4 Receptors
E. Y5 Receptors
F. y6 Receptors
G. Additional Sites
VI. Recommendations for Classification of Neuropeptide Y/Peptide
YY/Pancreatic Polypeptide-Mediated Responses
References
This article has been cited by other articles:
![]() |
M. Korner, B. Waser, and J. C. Reubi High Expression of Neuropeptide Y1 Receptors in Ewing Sarcoma Tumors Clin. Cancer Res., August 15, 2008; 14(16): 5043 - 5049. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. K. Jackson and Z. Mi Sitagliptin Augments Sympathetic Enhancement of the Renovascular Effects of Angiotensin II in Genetic Hypertension Hypertension, June 1, 2008; 51(6): 1637 - 1642. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. G. R. De Mey, R. Megens, and G. E. Fazzi Functional Antagonism between Endogenous Neuropeptide Y and Calcitonin Gene-Related Peptide in Mesenteric Resistance Arteries J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 930 - 937. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. K. Jackson, M. Zhang, W. Liu, and Z. Mi Inhibition of Renal Dipeptidyl Peptidase IV Enhances Peptide YY1 36-Induced Potentiation of Angiotensin II-Mediated Renal Vasoconstriction in Spontaneously Hypertensive Rats J. Pharmacol. Exp. Ther., November 1, 2007; 323(2): 431 - 437. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Fuzesi, G. Wittmann, Z. Liposits, R. M. Lechan, and C. Fekete Contribution of Noradrenergic and Adrenergic Cell Groups of the Brainstem and Agouti-Related Protein-Synthesizing Neurons of the Arcuate Nucleus to Neuropeptide-Y Innervation of Corticotropin-Releasing Hormone Neurons in Hypothalamic Paraventricular Nucleus of the Rat Endocrinology, November 1, 2007; 148(11): 5442 - 5450. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Pinilla, R. Fernandez-Fernandez, J. Roa, J. M. Castellano, M. Tena-Sempere, and E. Aguilar Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1385 - E1392. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. M. Kamiji and A. Inui Neuropeptide Y Receptor Selective Ligands in the Treatment of Obesity Endocr. Rev., October 1, 2007; 28(6): 664 - 684. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z.-Y. Chen, G.-G. Feng, K. Nishiwaki, Y. Shimada, Y. Fujiwara, T. Komatsu, and N. Ishikawa Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H959 - H967. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Yuzuriha, A. Inui, A. Asakawa, N. Ueno, M. Kasuga, M. M. Meguid, J.-i. Miyazaki, M. Ninomiya, H. Herzog, and M. Fujimiya Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development FASEB J, July 1, 2007; 21(9): 2108 - 2112. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Ribatti, M. T. Conconi, and G. G. Nussdorfer Nonclassic Endogenous Novel Regulators of Angiogenesis Pharmacol. Rev., June 1, 2007; 59(2): 185 - 205. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. M. Pelz and J. Dark ICV NPY Y1 receptor agonist but not Y5 agonist induces torpor-like hypothermia in cold-acclimated Siberian hamsters Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2299 - R2311. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. P. Silva, J. Lourenco, S. Xapelli, R. Ferreira, H. Kristiansen, D. P. D. Woldbye, C. R. Oliveira, and J. O. Malva Protein kinase C activity blocks neuropeptide Y-mediated inhibition of glutamate release and contributes to excitability of the hippocampus in status epilepticus FASEB J, March 1, 2007; 21(3): 671 - 681. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. R. Tough, N. D. Holliday, and H. M. Cox Y4 Receptors Mediate the Inhibitory Responses of Pancreatic Polypeptide in Human and Mouse Colon Mucosa J. Pharmacol. Exp. Ther., October 1, 2006; 319(1): 20 - 30. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Cavadas, D. Cefai, J. Rosmaninho-Salgado, M. A. Vieira-Coelho, E. Moura, N. Busso, T. Pedrazzini, D. Grand, S. Rotman, B. Waeber, et al. Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion PNAS, July 5, 2006; 103(27): 10497 - 10502. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. H. Dubinion, Z. Mi, C. Zhu, L. Gao, and E. K. Jackson Pancreatic Polypeptide-Fold Peptide Receptors and Angiotensin II-Induced Renal Vasoconstriction Hypertension, March 1, 2006; 47(3): 545 - 551. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Dumont, E. Moyse, A. Fournier, and R. Quirion Evidence for the Existence of an Additional Class of Neuropeptide Y Receptor Sites in Rat Brain J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 99 - 108. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Wettschureck and S. Offermanns Mammalian G Proteins and Their Cell Type Specific Functions Physiol Rev, October 1, 2005; 85(4): 1159 - 1204. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. D. Holliday, C.-W. Lam, I. R. Tough, and H. M. Cox Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization Mol. Pharmacol., March 1, 2005; 67(3): 655 - 664. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Wen, C. A. Parrish, D. Xu, Q. Wu, and P. Shen Drosophila neuropeptide F and its receptor, NPFR1, define a signaling pathway that acutely modulates alcohol sensitivity PNAS, February 8, 2005; 102(6): 2141 - 2146. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Lee, M. Hadi, G. Hallden, and G. W. Aponte Peptide YY and Neuropeptide Y Induce Villin Expression, Reduce Adhesion, and Enhance Migration in Small Intestinal Cells through the Regulation of CD63, Matrix Metalloproteinase-3, and Cdc42 Activity J. Biol. Chem., January 7, 2005; 280(1): 125 - 136. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Korner, B. Waser, and J. C. Reubi High Expression of Neuropeptide Y Receptors in Tumors of the Human Adrenal Gland and Extra-Adrenal Paraganglia Clin. Cancer Res., December 15, 2004; 10(24): 8426 - 8433. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Misra, K. S. Murthy, H. Zhou, and J. R. Grider Coexpression of Y1, Y2, and Y4 Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways J. Pharmacol. Exp. Ther., December 1, 2004; 311(3): 1154 - 1162. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. K. Chelikani, A. C. Haver, and R. D. Reidelberger Comparison of the inhibitory effects of PYY(3-36) and PYY(1-36) on gastric emptying in rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1064 - R1070. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. E. Humphries, M. J. Kimber, Y.-W. Barton, W. Hsu, N. J. Marks, B. Greer, P. Harriott, A. G. Maule, and T. A. Day Structure and Bioactivity of Neuropeptide F from the Human Parasites Schistosoma mansoni and Schistosoma japonicum J. Biol. Chem., September 17, 2004; 279(38): 39880 - 39885. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Kurimoto, Y.-S. Nan, Z.-Y. Chen, G.-G. Feng, T. Komatsu, N. Kandatsu, J. Ko, N. Kawai, and N. Ishikawa Effects of specific signal transduction inhibitors on increased permeability across rat endothelial monolayers induced by neuropeptide Y or VEGF Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H100 - H106. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y.-S. Nan, G.-G. Feng, Y. Hotta, K. Nishiwaki, Y. Shimada, A. Ishikawa, N. Kurimoto, T. Shigei, and N. Ishikawa Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1027 - H1033. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. M. Plant and M. L. Barker-Gibb Neurobiological mechanisms of puberty in higher primates Hum. Reprod. Update, January 1, 2004; 10(1): 67 - 77. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Nordheim and K. G. Hofbauer Stimulation of NPY Y2 receptors by PYY3-36 reveals divergent cardiovascular effects of endogenous NPY in rats on different dietary regimens Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R138 - R142. [Abstract] [Full Text] |
||||
![]() |
J. R. Grider and L. E. Langdon Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex Am J Physiol Gastrointest Liver Physiol, December 1, 2003; 285(6): G1139 - G1146. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. E.G. Lomax, K. A. Sharkey, and W. R. Giles Neuropeptide Y Modulates L-Type Ca2+ Current During Heart Development Circ. Res., November 14, 2003; 93(10): 891 - 892. [Full Text] [PDF] |
||||
![]() |
D. A. Drakulich, A. M. Walls, M. L. Toews, and T. D. Hexum Neuropeptide Y Receptor-Mediated Sensitization of ATP-Stimulated Inositol Phosphate Formation J. Pharmacol. Exp. Ther., November 1, 2003; 307(2): 559 - 565. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Bedoui, S. Miyake, Y. Lin, K. Miyamoto, S. Oki, N. Kawamura, A. Beck-Sickinger, S. von Horsten, and T. Yamamura Neuropeptide Y (NPY) Suppresses Experimental Autoimmune Encephalomyelitis: NPY1 Receptor-Specific Inhibition of Autoreactive Th1 Responses In Vivo J. Immunol., October 1, 2003; 171(7): 3451 - 3458. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Reubi Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy Endocr. Rev., August 1, 2003; 24(4): 389 - 427. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Simonneaux and C. Ribelayga Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters Pharmacol. Rev., June 1, 2003; 55(2): 325 - 395. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Toshinai, Y. Date, N. Murakami, M. Shimada, M. S. Mondal, T. Shimbara, J.-L. Guan, Q.-P. Wang, H. Funahashi, T. Sakurai, et al. Ghrelin-Induced Food Intake Is Mediated via the Orexin Pathway Endocrinology, April 1, 2003; 144(4): 1506 - 1512. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Dinger, J. E. Bader, A. D. Kobor, A. K. Kretzschmar, and A. G. Beck-Sickinger Homodimerization of Neuropeptide Y Receptors Investigated by Fluorescence Resonance Energy Transfer in Living Cells J. Biol. Chem., March 14, 2003; 278(12): 10562 - 10571. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. M. Berglund, P. A. Hipskind, and D. R. Gehlert Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes Experimental Biology and Medicine, March 1, 2003; 228(3): 217 - 244. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. A. Travagli, G. E. Hermann, K. N. Browning, and R. C. Rogers Musings on the Wanderer: What's New in our Understanding of Vago-Vagal Reflexes?: III. Activity-dependent plasticity in vago-vagal reflexes controlling the stomach Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G180 - G187. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bacci, J. R. Huguenard, and D. A. Prince Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons PNAS, December 24, 2002; 99(26): 17125 - 17130. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Fekete, S. Sarkar, W. M. Rand, J. W. Harney, C. H. Emerson, A. C. Bianco, A. Beck-Sickinger, and R. M. Lechan Neuropeptide Y1 and Y5 Receptors Mediate the Effects of Neuropeptide Y on the Hypothalamic-Pituitary-Thyroid Axis Endocrinology, December 1, 2002; 143(12): 4513 - 4519. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Bell, A. R. Allen, E. J. Kelso, A. Balasubramaniam, and B. J. McDermott Induction of Hypertrophic Responsiveness of Cardiomyocytes to Neuropeptide Y in Response to Pressure Overload J. Pharmacol. Exp. Ther., November 1, 2002; 303(2): 581 - 591. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bettio, M. C. Dinger, and A. G. Beck-Sickinger The neuropeptide Y monomer in solution is not folded in the pancreatic-polypeptide fold Protein Sci., July 1, 2002; 11(7): 1834 - 1844. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Galas, M.-C. Tonon, D. Beaujean, R. Fredriksson, D. Larhammar, I. Lihrmann, S. Jegou, A. Fournier, N. Chartrel, and H. Vaudry Neuropeptide Y Inhibits Spontaneous {alpha}-Melanocyte-Stimulating Hormone ({alpha}-MSH) Release via a Y5 Receptor and Suppresses Thyrotropin-Releasing Hormone-Induced {alpha}-MSH Secretion via a Y1 Receptor in Frog Melanotrope Cells Endocrinology, May 1, 2002; 143(5): 1686 - 1694. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Beaujean, J.-L. Do-Rego, L. Galas, A. G. Mensah-Nyagan, R. Fredriksson, D. Larhammar, A. Fournier, V. Luu-The, G. Pelletier, and H. Vaudry Neuropeptide Y Inhibits the Biosynthesis of Sulfated Neurosteroids in the Hypothalamus through Activation of Y1 Receptors Endocrinology, May 1, 2002; 143(5): 1950 - 1963. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Boehm and H. Kubista Fine Tuning of Sympathetic Transmitter Release via Ionotropic and Metabotropic Presynaptic Receptors Pharmacol. Rev., March 1, 2002; 54(1): 43 - 99. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Gicquiaux, S. Lecat, M. Gaire, A. Dieterlen, Y. Mely, K. Takeda, B. Bucher, and J.-L. Galzi Rapid Internalization and Recycling of the Human Neuropeptide Y Y1 Receptor J. Biol. Chem., February 15, 2002; 277(8): 6645 - 6655. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Pronchuk, A. G. Beck-Sickinger, and W. F. Colmers Multiple NPY Receptors Inhibit GABAA Synaptic Responses of Rat Medial Parvocellular Effector Neurons in the Hypothalamic Paraventricular Nucleus Endocrinology, February 1, 2002; 143(2): 535 - 543. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Cavadas, A. P. Silva, F. Mosimann, M. D. Cotrim, C. A. F. Ribeiro, H. R. Brunner, and E. Grouzmann NPY Regulates Catecholamine Secretion from Human Adrenal Chromaffin Cells J. Clin. Endocrinol. Metab., December 1, 2001; 86(12): 5956 - 5963. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Goumain, T. Voisin, A.-M. Lorinet, R. Ducroc, A. Tsocas, C. Roze, P. Rouet-Benzineb, H. Herzog, A. Balasubramaniam, and M. Laburthe The Peptide YY-Preferring Receptor Mediating Inhibition of Small Intestinal Secretion Is a Peripheral Y2 Receptor: Pharmacological Evidence and Molecular Cloning Mol. Pharmacol., July 1, 2001; 60(1): 124 - 134. [Abstract] [Full Text] |
||||
![]() |
J. C. Reubi, M. Gugger, B. Waser, and J.-C. Schaer Y1-Mediated Effect of Neuropeptide Y in Cancer: Breast Carcinomas as Targets Cancer Res., June 1, 2001; 61(11): 4636 - 4641. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. S. Corp, B. Greco, J. B. Powers, C. L. M. Bivens, and G. N. Wade Neuropeptide Y inhibits estrous behavior and stimulates feeding via separate receptors in Syrian hamsters Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1061 - R1068. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, M. Kojima, et al. Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway Diabetes, February 1, 2001; 50(2): 227 - 232. [Abstract] [Full Text] |
||||
![]() |
J. Robidoux, L. Simoneau, S. St-Pierre, A. Masse, and J. Lafond Characterization of Neuropeptide Y-Mediated Corticotropin-Releasing Factor Synthesis and Release from Human Placental Trophoblasts Endocrinology, August 1, 2000; 141(8): 2795 - 2804. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Hoyo, J. C. McGrath, and E. Vila Evidence for Y1-Receptor-Mediated Facilitatory, Modulatory Cotransmission by NPY in the Rat Anococcygeus Muscle J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 38 - 44. [Abstract] [Full Text] |
||||
![]() |
B.-S. Li, P. R. Kramer, W. Zhao, W. Ma, D. A. Stenger, and L. Zhang Molecular Cloning, Expression, and Characterization of Rat Homolog of Human AP-2{alpha} That Stimulates Neuropeptide Y Transcription Activity in Response to Nerve Growth Factor Mol. Endocrinol., June 1, 2000; 14(6): 837 - 847. [Abstract] [Full Text] |
||||
![]() |
A. Vezzani, M. Rizzi, M. Conti, and R. Samanin Modulatory Role of Neuropeptides in Seizures Induced in Rats by Stimulation of Glutamate Receptors J. Nutr., April 1, 2000; 130(4): 1046 - 1046. [Abstract] [Full Text] |
||||
![]() |
A. Wraith, A. Törnsten, P. Chardon, I. Harbitz, B. P. Chowdhary, L. Andersson, L.-G. Lundin, and D. Larhammar Evolution of the Neuropeptide Y Receptor Family: Gene and Chromosome Duplications Deduced from the Cloning and Mapping of the Five Receptor Subtype Genes in Pig Genome Res., March 1, 2000; 10(3): 302 - 310. [Abstract] [Full Text] |
||||
![]() |
A. Inui Transgenic Approach to the Study of Body Weight Regulation Pharmacol. Rev., March 1, 2000; 52(1): 35 - 62. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. W. Y. Ho, A. G. Beck-Sickinger, and W. F. Colmers Neuropeptide Y5 Receptors Reduce Synaptic Excitation in Proximal Subiculum, But Not Epileptiform Activity in Rat Hippocampal Slices J Neurophysiol, February 1, 2000; 83(2): 723 - 734. [Abstract] [Full Text] [PDF] |
||||