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Vol. 50, Issue 1, 21-34, March 1998
Department of Pharmacology, Kyoto Prefectural University of
Medicine, Kyoto, Japan
I. Introduction
II. Aldose Reductase and Aldo-Keto Reductase Superfamily
A. Aldose Reductase as a Member of the Aldo-Keto Reductase
Superfamily
B. A Closely Related Subgroup in the Aldo-Keto Reductase
Superfamily
C. Tertiary Structure of Aldose Reductase
III. Physiological Significance of Aldose Reductase
A. Polyol Pathway First Identified in the Seminal Vesicle
B. Osmoregulatory Role in the Kidney
C. Unique Tissue Distribution Pattern of Aldose Reductase
D. Diverse Substrates for Aldose Reductase
IV. Aldose Reductase in Glucose Toxicity
A. Effect of Accelerated Polyol Pathway
B. Transgenic Animal Model
C. Hemodynamic Abnormalities in Diabetic Neuropathy
D. Aldose Reductase and Other Factors in Glucose Toxicity
V. A Potential Target for the Prevention of Diabetic Complications
A. Clinical Trials of Aldose Reductase Inhibitors
B. Variable Levels of Aldose Reductase in Diabetic Patients
VI. Conclusions
References
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