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Vol. 50, Issue 3, 335-356, September 1998

Endogenous Glutathione Conjugates: Occurrence and Biological Functions

Wei Wang and Nazzareno Ballatoria

Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York

I. Introduction
II. Glutathione Homeostasis
    A. Synthesis and Degradation
    B. Biological Functions
        1. Regulation of cellular sulfhydryl status.
        2. Conjugation of electrophiles and metals.
III. Endogenous Glutathione Thioethers
    A. Leukotriene C4 (LTC4)
        1. Synthesis and biological actions.
        2. Leukotriene metabolism.
    B. Prostaglandins
    C. Hepoxilins
    D. Nitric Oxide
    E. Hydroxyalkenals
    F. Ascorbic Acid
    G. Dopa and Dopamine
    H. Maleic Acid
    I. Methylglyoxal
IV. Glutathione Amides: Glutathionylspermidine and Trypanothione
V. Glutathione Thioesters
VI. Glutathione Mercaptides
    A. Copper
    B. Selenium
VII. Summary
References

a   Address for correspondence: Ned Ballatori, Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642. E-mail: Ballatorin{at}envmed.rochester.edu.

0031-6997/98/5003-0335$03.00/0
PHARMACOLOGICAL REVIEWS
Copyright © 1998 by The American Society for Pharmacology and Experimental Therapeutics


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