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Vol. 50, Issue 3, 357-386, September 1998
Centre Hospitalier Universitaire de Québec (F.M., D.B.R.),
Centre de recherche du Pavillon L'Hôtel-Dieu de Québec,
Québec, Canada;
Human Genetics (J.F.H.), Merck Research
Laboratories, West Point, Pennsylvania
Foreword
I. Introduction: The B1 Receptors in the
Kallikrein-Kinin System
A. Older and Novel Molecular Elements of the Kallikrein-Kinin
System
B. Current Issues in the Analytical Chemistry and Metabolism of
Kinins
II. Seven Criteria to Classify Kinin Receptors into the
B1 and B2 Subtypes
A. Potency Order of Agonists
B. Affinities of Antagonists
C. Absence of Cross-Desensitization
D. Second-Messengers
E. Distinct Nucleotide/Amino Acid Sequences
F. Targeted Disruption of Receptor Genes
G. Distinct Regulatory Profile
III. Immunological and Molecular Analysis of B1
Receptor Regulation by Tissue Injury
A. Postisolation B1 Receptor Induction in Tissues
B. In Vivo Paradigms for the Induction of the B1
Receptors and Their In Vitro Correlates
C. Controversies and Exceptional Situations
D. Analysis of the Promoter Function of the B1 Receptor
Gene
E. Allelic Polymorphisms of the B1 Receptor in the
Human Population and Human Disease
IV. Physiopathological Relevance of B1 Receptor
Up-Regulation
A. Circulation
B. Inflammation, Neurogenic Inflammation
C. Pain, Hyperalgesia, and Fever
D. Nephrology and Urology
E. Others
1. Fibrosis.
2. Gastroenterology.
V. Conclusions
VI. Addendum
Acknowledgments
References
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S. B. Phagoo, K. Reddi, K. D. Anderson, L. M. F. Leeb-Lundberg, and D. Warburton Bradykinin B1 Receptor Up-Regulation by Interleukin-1beta and B1 Agonist Occurs through Independent and Synergistic Intracellular Signaling Mechanisms in Human Lung Fibroblasts J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 77 - 85. [Abstract] [Full Text]
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M. Cyr, Y. Lepage, C. Blais Jr., N. Gervais, M. Cugno, J.-L. Rouleau, and A. Adam Bradykinin and des-Arg9-bradykinin metabolic pathways and kinetics of activation of human plasma Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H275 - H283. [Abstract] [Full Text] [PDF]
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C. D. Figueroa, C. Chacón, J. Corthorn, P. Ehrenfeld, W. Müller-Esterl, and G. Valdés Temporospatial Changes of Kinin B2 Receptors During the Estrous Cycle and Pregnancy in the Rat Uterus Biol Reprod, June 1, 2001; 64(6): 1590 - 1599. [Abstract] [Full Text]
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M. Tramontana, A. Lecci, S. Meini, X. Montserrat, J. Pascual, S. Giuliani, L. Quartara, and C. A. Maggi Differences between Peptide and Nonpeptide B2 Bradykinin Receptor Antagonists in Blocking Bronchoconstriction and Hypotension Induced by Bradykinin in Anesthetized Guinea Pigs J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 1051 - 1057. [Abstract] [Full Text]
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I. Duka, E. Kintsurashvili, I. Gavras, C. Johns, M. Bresnahan, and H. Gavras Vasoactive Potential of the B1 Bradykinin Receptor in Normotension and Hypertension Circ. Res., February 16, 2001; 88(3): 275 - 281. [Abstract] [Full Text] [PDF]
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C Mazenot, L Loufrani, D Henrion, C Ribuot, W Muller-Esterl, and D Godin-Ribuot Endothelial kinin B1-receptors are induced by myocardial ischaemia-reperfusion in the rabbit J. Physiol., January 1, 2001; 530(1): 69 - 78. [Abstract] [Full Text] [PDF]
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S. Böckmann and I. Paegelow Kinins and kinin receptors: importance for the activation of leukocytes J. Leukoc. Biol., November 1, 2000; 68(5): 587 - 592. [Abstract] [Full Text]
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L. J. Murphey, S. Kumar, and N. J. Brown Endogenous Bradykinin and the Renin and Pressor Responses to Furosemide in Humans J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 644 - 648. [Abstract] [Full Text]
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P. G. McLean, M. Perretti, and A. Ahluwalia Kinin B1 receptors and the cardiovascular system: regulation of expression and function Cardiovasc Res, November 1, 2000; 48(2): 194 - 210. [Abstract] [Full Text] [PDF]
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M H Sarker, D-E Hu, and P A Fraser Acute effects of bradykinin on cerebral microvascular permeability in the anaesthetized rat J. Physiol., October 1, 2000; 528(1): 177 - 187. [Abstract] [Full Text] [PDF]
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 P. G. McLean, A. Ahluwalia, and M. Perretti Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules J. Exp. Med., July 31, 2000; 192(3): 367 - 380. [Abstract] [Full Text] [PDF]
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S. Houle, M. Landry, R. Audet, J. Bouthillier, D. R. Bachvarov, and F. Marceau Effect of Allelic Polymorphism of the B1 and B2 Receptor Genes on the Contractile Responses of the Human Umbilical Vein to Kinins J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 45 - 51. [Abstract] [Full Text]
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 J. P. SCHANSTRA, M. E. MARIN-CASTAÑO, F. PRADDAUDE, I. TACK, J.-L. ADER, J.-P. GIROLAMI, J.-L. BASCANDS, and B. JEUNIER Bradykinin B1 Receptor-Mediated Changes in Renal Hemodynamics during Endotoxin-Induced Inflammation J. Am. Soc. Nephrol., July 1, 2000; 11(7): 1208 - 1215. [Abstract] [Full Text]
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 D. Regoli Toward a new anti-inflammatory and analgesic agent PNAS, June 23, 2000; (2000) 150233397. [Full Text]
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J. B. Pesquero, R. C. Araujo, P. A. Heppenstall, C. L. Stucky, J. A. Silva Jr., T. Walther, S. M. Oliveira, J. L. Pesquero, A. C. M. Paiva, J. B. Calixto, et al. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors PNAS, June 14, 2000; (2000) 120035997. [Abstract] [Full Text]
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D. A. Ricupero, J. R. Romero, D. C. Rishikof, and R. H. Goldstein Des-Arg10-kallidin Engagement of the B1 Receptor Stimulates Type I Collagen Synthesis via Stabilization of Connective Tissue Growth Factor mRNA J. Biol. Chem., April 21, 2000; 275(17): 12475 - 12480. [Abstract] [Full Text] [PDF]
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J. B. Su, R. Houel, F. Heloire, F. Barbe, F. Beverelli, L. Sambin, A. Castaigne, A. Berdeaux, B. Crozatier, and L. Hittinger Stimulation of Bradykinin B1 Receptors Induces Vasodilation in Conductance and Resistance Coronary Vessels in Conscious Dogs : Comparison With B2 Receptor Stimulation Circulation, April 18, 2000; 101(15): 1848 - 1853. [Abstract] [Full Text] [PDF]
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S. Bastian, D. Pruneau, B. Loillier, C. Robert, J.-C. Bonnafous, and J.-L. Paquet Identification of a Key Region of Kinin B1 Receptor for High Affinity Binding of Peptide Antagonists J. Biol. Chem., February 25, 2000; 275(9): 6107 - 6113. [Abstract] [Full Text] [PDF]
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S B Deshpande, S Bagchi, O P Rai, and N C Aryya Pulmonary oedema produced by scorpion venom augments a phenyldiguanide-induced reflex response in anaesthetized rats J. Physiol., December 1, 1999; 521(2): 537 - 544. [Abstract] [Full Text] [PDF]
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 F. Marceau, J.-F. Larrivee, J. Bouthillier, M. Bachvarova, S. Houle, and D. R. Bachvarov Effect of endogenous kinins, prostanoids, and NO on kinin B1 and B2 receptor expression in the rabbit Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1999; 277(6): R1568 - R1578. [Abstract] [Full Text] [PDF]
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 C. Blais Jr., A. Adam, D. Massicotte, and F. Peronnet Increase in blood bradykinin concentration after eccentric weight-training exercise in men J Appl Physiol, September 1, 1999; 87(3): 1197 - 1201. [Abstract] [Full Text] [PDF]
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S. P. Sardi, F. M. Daray, A. E. Errasti, F. G. Pelorosso, V. A. Pujol-Lereis, V. Rey-Ares, M. P. Rogines-Velo, and R. P. Rothlin Further Pharmacological Characterization of Bradykinin B1 Receptor Up-Regulation in Human Umbilical Vein J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1019 - 1025. [Abstract] [Full Text]
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S. B. Phagoo, S. Poole, and L. M. F. Leeb-Lundberg Autoregulation of Bradykinin Receptors: Agonists in the Presence of Interleukin-1beta Shift the Repertoire of Receptor Subtypes from B2 to B1 in Human Lung Fibroblasts Mol. Pharmacol., August 1, 1999; 56(2): 325 - 333. [Abstract] [Full Text]
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L. M. F. Leeb-Lundberg, D. S. Kang, M. E. Lamb, and D. B. Fathy The Human B1 Bradykinin Receptor Exhibits High Ligand-independent, Constitutive Activity. ROLES OF RESIDUES IN THE FOURTH INTRACELLULAR AND THIRD TRANSMEMBRANE DOMAINS J. Biol. Chem., March 16, 2001; 276(12): 8785 - 8792. [Abstract] [Full Text] [PDF]
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J. B. Pesquero, R. C. Araujo, P. A. Heppenstall, C. L. Stucky, J. A. Silva Jr., T. Walther, S. M. Oliveira, J. L. Pesquero, A. C. M. Paiva, J. B. Calixto, et al. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors PNAS, July 5, 2000; 97(14): 8140 - 8145. [Abstract] [Full Text] [PDF]
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D. Regoli Toward a new anti-inflammatory and analgesic agent PNAS, July 5, 2000; 97(14): 7676 - 7677. [Full Text] [PDF]
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 K. Nakamura, A. Zuppini, S. Arnaudeau, J. Lynch, I. Ahsan, R. Krause, S. Papp, H. De Smedt, J. B. Parys, W. Muller-Esterl, et al. Functional specialization of calreticulin domains J. Cell Biol., September 3, 2001; 154(5): 961 - 972. [Abstract] [Full Text] [PDF]
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