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Vol. 50, Issue 3, 357-386, September 1998
Centre Hospitalier Universitaire de Québec (F.M., D.B.R.),
Centre de recherche du Pavillon L'Hôtel-Dieu de Québec,
Québec, Canada;
Human Genetics (J.F.H.), Merck Research
Laboratories, West Point, Pennsylvania
Foreword
I. Introduction: The B1 Receptors in the
Kallikrein-Kinin System
A. Older and Novel Molecular Elements of the Kallikrein-Kinin
System
B. Current Issues in the Analytical Chemistry and Metabolism of
Kinins
II. Seven Criteria to Classify Kinin Receptors into the
B1 and B2 Subtypes
A. Potency Order of Agonists
B. Affinities of Antagonists
C. Absence of Cross-Desensitization
D. Second-Messengers
E. Distinct Nucleotide/Amino Acid Sequences
F. Targeted Disruption of Receptor Genes
G. Distinct Regulatory Profile
III. Immunological and Molecular Analysis of B1
Receptor Regulation by Tissue Injury
A. Postisolation B1 Receptor Induction in Tissues
B. In Vivo Paradigms for the Induction of the B1
Receptors and Their In Vitro Correlates
C. Controversies and Exceptional Situations
D. Analysis of the Promoter Function of the B1 Receptor
Gene
E. Allelic Polymorphisms of the B1 Receptor in the
Human Population and Human Disease
IV. Physiopathological Relevance of B1 Receptor
Up-Regulation
A. Circulation
B. Inflammation, Neurogenic Inflammation
C. Pain, Hyperalgesia, and Fever
D. Nephrology and Urology
E. Others
1. Fibrosis.
2. Gastroenterology.
V. Conclusions
VI. Addendum
Acknowledgments
References
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E. G Erdos Kinins, the long march--A personal view Cardiovasc Res, June 1, 2002; 54(3): 485 - 491. [Full Text] [PDF]
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