| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Vol. 50, Issue 4, 515-596, December 1998
Department of Thoracic Medicine (P.J.B., K.F.C),
National
Heart and Lung Institute, Imperial College, and Department of
Pharmacology (C.P.P), Kings College, London, United Kingdom
I. Introduction
A. Cellular Origin of Mediators
B. Synthesis and Metabolism
C. Mediator Receptors
D. Mediator Effects
E. Involvement of Mediators in Asthma
F. Chronic Inflammation
G. Transcription Factors
H. Mediator Interactions
II. Amine Mediators
A. Histamine
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
B. Serotonin (5-Hydroxytryptamine)
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
C. Adenosine
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
III. Lipid-Derived Mediators
A. Prostanoids
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
B. Leukotrienes
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
C. Platelet-Activating Factor
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
D. Other Lipid Mediators
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
IV. Peptide Mediators
A. Bradykinin
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
B. Tachykinins
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
C. Calcitonin Gene-Related Peptide
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
D. Endothelins
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
E. Complement
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
V. Small Molecules
A. Reactive Oxygen Species
1. Synthesis and metabolism.
2. Effects on airways.
3. Role in asthma.
B. Nitric Oxide
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
VI. Cytokines
A. General Overview
1. The cytokine network in chronic inflammation.
2. Cytokine receptors.
B. Lymphokines
1. Interleukin-2.
2. Interleukin-3.
3. Interleukin-4.
4. Interleukin-5.
5. Interleukin-13.
6. Interleukin-15.
7. Interleukin-16.
8. Interleukin-17.
C. Proinflammatory Cytokines
1. Interleukin-1.
2. Tumor necrosis factor-
.
3. Interleukin-6.
4. Interleukin-11.
5. Granulocyte-macrophage colony-stimulating factor.
6. Stem cell factor.
D. Inhibitory Cytokines
1. Interleukin-10.
2. Interleukin-1 receptor antagonist.
3. Interferon-
.
4. Interleukin-12.
5. Interleukin-18.
E. Growth Factors
1. Platelet-derived growth factor.
2. Transforming growth factor-
.
3. Fibroblast growth factor.
4. Epidermal growth factor.
5. Insulin-like growth factor.
VII. Chemokines
A. CC Chemokines
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
B. CXC Chemokines
1. Synthesis and metabolism.
2. Receptors.
3. Effects on airways.
4. Role in asthma.
VIII. Proteases
A. Synthesis and Metabolism
B. Receptors
C. Effects on Airways
1. Airway smooth muscle.
2. Other effects.
D. Role in Asthma
1. Release.
2. Effects of inhibitors.
References
This article has been cited by other articles:
|
|
 |
|
  G. M. Bohmer, N. Nassr, M. Wenger, A. Hunnemeyer, G. Lahu, S. Templin, C. H. Gleiter, and R. Hermann The Targeted Oral, Once-Daily Phosphodiesterase 4 Inhibitor Roflumilast and the Leukotriene Receptor Antagonist Montelukast Do Not Exhibit Significant Pharmacokinetic Interactions J. Clin. Pharmacol., April 1, 2009; 49(4): 389 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhai, Z. Zhong, C.-Y. A. Chen, Z. Xia, L. Song, M. R. Blackburn, and A.-B. Shyu Coordinated Changes in mRNA Turnover, Translation, and RNA Processing Bodies in Bronchial Epithelial Cells following Inflammatory Stimulation Mol. Cell. Biol., December 15, 2008; 28(24): 7414 - 7426. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nadeem, A. Masood, and N. Siddiqui Review: Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options Therapeutic Advances in Respiratory Disease, August 1, 2008; 2(4): 215 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Willets, A. H. Taylor, H. Shaw, J. C. Konje, and R. A. J. Challiss Selective Regulation of H1 Histamine Receptor Signaling by G Protein-Coupled Receptor Kinase 2 in Uterine Smooth Muscle Cells Mol. Endocrinol., August 1, 2008; 22(8): 1893 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Quante, Y. C. Ng, E. E. Ramsay, S. Henness, J. C. Allen, J. Parmentier, Q. Ge, and A. J. Ammit Corticosteroids Reduce IL-6 in ASM Cells via Up-Regulation of MKP-1 Am. J. Respir. Cell Mol. Biol., August 1, 2008; 39(2): 208 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Sabnis, C. A. Reilly, J. M. Veranth, and G. S. Yost Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures Am J Physiol Lung Cell Mol Physiol, July 1, 2008; 295(1): L194 - L200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C-H. Hung, Y-T. Chu, Y-M. Hua, S-H. Hsu, C-S. Lin, H-C. Chang, M-S. Lee, and Y-J. Jong Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells Eur. Respir. J., June 1, 2008; 31(6): 1313 - 1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. P. Nguyen, O. Omoluabi, S. Parra, J. M. Frieske, C. Clement, Z. Ammar-Aouchiche, S. B. Ho, C. Ehre, M. Kesimer, B. J. Knoll, et al. Chronic Exposure to Beta-Blockers Attenuates Inflammation and Mucin Content in a Murine Asthma Model Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 256 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Coffman, J. C. Brown, D. A. Johnson, N. Parthasarathy, R. B. D'Agostino Jr., M. O. Lively, X. Hua, S. L. Tilley, W. Muller-Esterl, M. C. Willingham, et al. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L505 - L515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Shiraishi, K. Asano, K. Niimi, K. Fukunaga, M. Wakaki, J. Kagyo, T. Takihara, S. Ueda, T. Nakajima, T. Oguma, et al. Cyclooxygenase-2/Prostaglandin D2/CRTH2 Pathway Mediates Double-Stranded RNA-Induced Enhancement of Allergic Airway Inflammation J. Immunol., January 1, 2008; 180(1): 541 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S McLeish and S W Turner Gene environment interactions in asthma Arch. Dis. Child., November 1, 2007; 92(11): 1032 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nadeem, M. Fan, H. R. Ansari, C. Ledent, and S. Jamal Mustafa Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1335 - L1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tigani, C. Cannet, H. Karmouty-Quintana, F.-X. Ble, S. Zurbruegg, E. Schaeublin, J. R. Fozard, and N. Beckmann Lung inflammation and vascular remodeling after repeated allergen challenge detected noninvasively by MRI Am J Physiol Lung Cell Mol Physiol, March 1, 2007; 292(3): L644 - L653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Szema, S. A. Hamidi, S. Lyubsky, K. G. Dickman, S. Mathew, T. Abdel-Razek, J. J. Chen, J. A. Waschek, and S. I. Said Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP Am J Physiol Lung Cell Mol Physiol, November 1, 2006; 291(5): L880 - L886. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. K. Quintana, C. Cannet, E. Schaeublin, S. Zurbruegg, R. Sugar, L. Mazzoni, C. P. Page, J. R. Fozard, and N. Beckmann Identification with MRI of the pleura as a major site of the acute inflammatory effects induced by ovalbumin and endotoxin challenge in the airways of the rat Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L651 - L657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Against the dutch hypothesis: asthma and chronic obstructive pulmonary disease are distinct diseases. Am. J. Respir. Crit. Care Med., August 1, 2006; 174(3): 240 - 243. [Full Text] [PDF]
|
|
|
|
 |
|
 E Hothersall, C McSharry, and N C Thomson Potential therapeutic role for statins in respiratory disease. Thorax, August 1, 2006; 61(8): 729 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. M. Shim, Z. Zhu, T. Zheng, C. G. Lee, R. J. Homer, B. Ma, and J. A. Elias Role of 5-Lipoxygenase in IL-13-Induced Pulmonary Inflammation and Remodeling J. Immunol., August 1, 2006; 177(3): 1918 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes Corticosteroid effects on cell signalling Eur. Respir. J., February 1, 2006; 27(2): 413 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Horvath and A. Wanner Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma Eur. Respir. J., January 1, 2006; 27(1): 172 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Y Liew, M Patel, and D Xu Toll-like receptor 2 signalling and inflammation Ann Rheum Dis, November 1, 2005; 64(suppl_4): iv104 - iv105. [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Biernacki, S. A. Kharitonov, H. M. Biernacka, and P. J. Barnes Effect of Montelukast on Exhaled Leukotrienes and Quality of Life in Asthmatic Patients Chest, October 1, 2005; 128(4): 1958 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. F. Chung Evaluation of Selective Prostaglandin E2 (PGE2) Receptor Agonists as Therapeutic Agents for the Treatment of Asthma Sci. Signal., September 27, 2005; 2005(303): pe47 - pe47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Frossard, E. Naline, C. Olgart Hoglund, O. Georges, and C. Advenier Nerve growth factor is released by IL-1{beta} and induces hyperresponsiveness of the human isolated bronchus Eur. Respir. J., July 1, 2005; 26(1): 15 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Patel, D. Xu, P. Kewin, B. Choo-Kang, C. McSharry, N. C. Thomson, and F. Y. Liew TLR2 Agonist Ameliorates Established Allergic Airway Inflammation by Promoting Th1 Response and Not via Regulatory T Cells J. Immunol., June 15, 2005; 174(12): 7558 - 7563. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nie, L. Corbett, A. J. Knox, and L. Pang Differential Regulation of Chemokine Expression by Peroxisome Proliferator-activated Receptor {gamma} Agonists: INTERACTIONS WITH GLUCOCORTICOIDS AND {beta}2-AGONISTS J. Biol. Chem., January 28, 2005; 280(4): 2550 - 2561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Iwata, J. Luo, R. B. Penn, and J. L. Benovic Bimodal Regulation of the Human H1 Histamine Receptor by G Protein-coupled Receptor Kinase 2 J. Biol. Chem., January 21, 2005; 280(3): 2197 - 2204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Distribution of Receptor Targets in the Lung Proceedings of the ATS, December 1, 2004; 1(4): 345 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes Mediators of Chronic Obstructive Pulmonary Disease Pharmacol. Rev., December 1, 2004; 56(4): 515 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Zuberi, D. K. Hsu, O. Kalayci, H.-Y. Chen, H. K. Sheldon, L. Yu, J. R. Apgar, T. Kawakami, C. M. Lilly, and F.-T. Liu Critical Role for Galectin-3 in Airway Inflammation and Bronchial Hyperresponsiveness in a Murine Model of Asthma Am. J. Pathol., December 1, 2004; 165(6): 2045 - 2053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Adcock, K. Ito, and P. J. Barnes Glucocorticoids: Effects on Gene Transcription Proceedings of the ATS, November 1, 2004; 1(3): 247 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Forssmann, I. Hartung, R. Balder, B. Fuchs, S. E. Escher, N. Spodsberg, Y. Dulkys, M. Walden, A. Heitland, A. Braun, et al. n-Nonanoyl-CC Chemokine Ligand 14, a Potent CC Chemokine Ligand 14 Analogue That Prevents the Recruitment of Eosinophils in Allergic Airway Inflammation J. Immunol., September 1, 2004; 173(5): 3456 - 3466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kim, L. McKinley, J. Siddiqui, G. L. Bolgos, and D. G. Remick Prevention and reversal of pulmonary inflammation and airway hyperresponsiveness by dexamethasone treatment in a murine model of asthma induced by house dust Am J Physiol Lung Cell Mol Physiol, September 1, 2004; 287(3): L503 - L509. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. I. Berro, G. A. Perry, and D. K. Agrawal Increased Expression and Activation of CD30 Induce Apoptosis in Human Blood Eosinophils J. Immunol., August 1, 2004; 173(3): 2174 - 2183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Cap, J Chladek, F Pehal, M Maly, V Petru, P J Barnes, and P Montuschi Gas chromatography/mass spectrometry analysis of exhaled leukotrienes in asthmatic patients Thorax, June 1, 2004; 59(6): 465 - 470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ishii, T. Nagase, H. Shindou, H. Takizawa, Y. Ouchi, and T. Shimizu Platelet-Activating Factor Receptor Develops Airway Hyperresponsiveness Independently of Airway Inflammation in a Murine Asthma Model J. Immunol., June 1, 2004; 172(11): 7095 - 7102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Feistritzer, N. C. Kaneider, D. H. Sturn, B. A. Mosheimer, C. M. Kahler, and C. J. Wiedermann Expression and Function of the Vascular Endothelial Growth Factor Receptor FLT-1 in Human Eosinophils Am. J. Respir. Cell Mol. Biol., May 1, 2004; 30(5): 729 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McKay, B. P. Leung, I. B. McInnes, N. C. Thomson, and F. Y. Liew A Novel Anti-Inflammatory Role of Simvastatin in a Murine Model of Allergic Asthma J. Immunol., March 1, 2004; 172(5): 2903 - 2908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Caramori and A Papi Oxidants and asthma Thorax, February 1, 2004; 59(2): 170 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Galijasevic, G. M. Saed, M. P. Diamond, and H. M. Abu-Soud Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition PNAS, December 9, 2003; 100(25): 14766 - 14771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takeshita, K. Sakai, K. B. Bacon, and F. Gantner Critical Role of Histamine H4 Receptor in Leukotriene B4 Production and Mast Cell-Dependent Neutrophil Recruitment Induced by Zymosan in Vivo J. Pharmacol. Exp. Ther., December 1, 2003; 307(3): 1072 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kostikas, G. Papatheodorou, K. Psathakis, P. Panagou, and S. Loukides Prostaglandin E2 in the expired breath condensate of patients with asthma Eur. Respir. J., November 1, 2003; 22(5): 743 - 747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. McElhinney, M. E. Poynter, P. Shrivastava, S. L. Hazen, and Y. M. W. Janssen-Heininger Eosinophil peroxidase catalyzes JNK-mediated membrane blebbing in a Rho kinase-dependent manner J. Leukoc. Biol., November 1, 2003; 74(5): 897 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saito, T. Yajima, H. Nishimura, K. Aiba, R. Ishimitsu, T. Matsuguchi, T. Fushimi, Y. Ohshima, Y. Tsukamoto, and Y. Yoshikai Soluble Branched {beta}-(1,4)Glucans from Acetobacter Species Show Strong Activities to Induce Interleukin-12 in Vitro and Inhibit T-helper 2 Cellular Response with Immunoglobulin E Production in Vivo J. Biol. Chem., October 3, 2003; 278(40): 38571 - 38578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Barnes and I. M. Adcock How Do Corticosteroids Work in Asthma? Ann Intern Med, September 2, 2003; 139(5_Part_1): 359 - 370. [Full Text] [PDF]
|
|
|
|
|
|
D. Rodriguez, A. C. Keller, E. L. Faquim-Mauro, M. S. de Macedo, F. Q. Cunha, J. Lefort, B. B. Vargaftig, and M. Russo Bacterial Lipopolysaccharide Signaling Through Toll-Like Receptor 4 Suppresses Asthma-Like Responses Via Nitric Oxide Synthase 2 Activity J. Immunol., July 15, 2003; 171(2): 1001 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Baraldi, L. Ghiro, V. Piovan, S. Carraro, G. Ciabattoni, P. J. Barnes, and P. Montuschi Increased Exhaled 8-Isoprostane in Childhood Asthma Chest, July 1, 2003; 124(1): 25 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Soukhova, Y. Wang, M. Ahmed, J. F. Walker, and J. Yu Bradykinin stimulates respiratory drive by activating pulmonary sympathetic afferents in the rabbit J Appl Physiol, July 1, 2003; 95(1): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Poynter, C. G. Irvin, and Y. M. W. Janssen-Heininger A Prominent Role for Airway Epithelial NF-{kappa}B Activation in Lipopolysaccharide-Induced Airway Inflammation J. Immunol., June 15, 2003; 170(12): 6257 - 6265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Koarai, M. Ichinose, S. Ishigaki-Suzuki, S. Yamagata, H. Sugiura, E. Sakurai, Y. Makabe-Kobayashi, A. Kuramasu, T. Watanabe, K. Shirato, et al. Disruption of L-Histidine Decarboxylase Reduces Airway Eosinophilia but not Hyperresponsiveness Am. J. Respir. Crit. Care Med., March 1, 2003; 167(5): 758 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-Y. Eum, K. Maghni, Q. Hamid, H. Campbell, D. H. Eidelman, and J. G. Martin Involvement of the Cysteinyl-Leukotrienes in Allergen-Induced Airway Eosinophilia and Hyperresponsiveness in the Mouse Am. J. Respir. Cell Mol. Biol., January 1, 2003; 28(1): 25 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Song, W. Ning, F. Liu, B. T. Ameredes, W. J. Calhoun, L. E. Otterbein, and A. M. K. Choi Regulation of IL-1beta -induced GM-CSF production in human airway smooth muscle cells by carbon monoxide Am J Physiol Lung Cell Mol Physiol, January 1, 2003; 284(1): L50 - L56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gantner, K. Sakai, M. W. Tusche, W. W. Cruikshank, D. M. Center, and K. B. Bacon Histamine H4 and H2 Receptors Control Histamine-Induced Interleukin-16 Release from Human CD8+ T Cells J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 300 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Koarai, M. Ichinose, H. Sugiura, M. Tomaki, M. Watanabe, S. Yamagata, Y. Komaki, K. Shirato, and T. Hattori iNOS depletion completely diminishes reactive nitrogen-species formation after an allergic response Eur. Respir. J., September 1, 2002; 20(3): 609 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Freund, F. Pons, V. Joly, E. Mathieu, N. Martinet, and N. Frossard Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions Eur. Respir. J., August 1, 2002; 20(2): 458 - 463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Toward and K. J. Broadley Goblet Cell Hyperplasia, Airway Function, and Leukocyte Infiltration after Chronic Lipopolysaccharide Exposure in Conscious Guinea Pigs: Effects of Rolipram and Dexamethasone J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 814 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ito, G. Caramori, S. Lim, T. Oates, K. F. Chung, P. J. Barnes, and I. M. Adcock Expression and Activity of Histone Deacetylases in Human Asthmatic Airways Am. J. Respir. Crit. Care Med., August 1, 2002; 166(3): 392 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ito, S. Lim, G. Caramori, B. Cosio, K. F. Chung, I. M. Adcock, and P. J. Barnes A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression PNAS, June 25, 2002; 99(13): 8921 - 8926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Hashimoto, R S Peebles Jr, J R Sheller, K Jarzecka, J Furlong, D B Mitchell, T V Hartert, and B S Graham Suppression of airway hyperresponsiveness induced by ovalbumin sensitisation and RSV infection with Y-27632, a Rho kinase inhibitor Thorax, June 1, 2002; 57(6): 524 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Melendez and A. K. Khaw Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells J. Biol. Chem., May 3, 2002; 277(19): 17255 - 17262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Poynter, C. G. Irvin, and Y. M. W. Janssen-Heininger Rapid Activation of Nuclear Factor-{kappa}B in Airway Epithelium in a Murine Model of Allergic Airway Inflammation Am. J. Pathol., April 1, 2002; 160(4): 1325 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.D. Message and S.L. Johnston The immunology of virus infection in asthma Eur. Respir. J., December 1, 2001; 18(6): 1013 - 1025. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Bakker, S. B. J. Schoonus, M. J. Smit, H. Timmerman, and R. Leurs Histamine H1-Receptor Activation of Nuclear Factor-kappa B: Roles for Gbeta gamma - and Galpha q/11-Subunits in Constitutive and Agonist-Mediated Signaling Mol. Pharmacol., November 1, 2001; 60(5): 1133 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Abe, K. Shibata, H. Akatsu, N. Shimizu, N. Sakata, T. Katsuragi, and H. Okada Contribution of Anaphylatoxin C5a to Late Airway Responses After Repeated Exposure of Antigen to Allergic Rats J. Immunol., October 15, 2001; 167(8): 4651 - 4660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Emelyanov, G. Fedoseev, A. Abulimity, K. Rudinski, A. Fedoulov, A. Karabanov, and P. J. Barnes Elevated Concentrations of Exhaled Hydrogen Peroxide in Asthmatic Patients Chest, October 1, 2001; 120(4): 1136 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. DUGUET, H. IIJIMA, S.-Y. EUM, Q. HAMID, and D. H. EIDELMAN Eosinophil Peroxidase Mediates Protein Nitration in Allergic Airway Inflammation in Mice Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1119 - 1126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Monneret, S. Gravel, M. Diamond, J. Rokach, and W. S. Powell Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor Blood, September 15, 2001; 98(6): 1942 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.J. Barnes Cytokine modulators as novel therapies for airway disease Eur. Respir. J., July 2, 2001; 18(34_suppl): 67S - 77s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Olgart and N. Frossard Human lung fibroblasts secrete nerve growth factor: effect of inflammatory cytokines and glucocorticoids Eur. Respir. J., July 1, 2001; 18(1): 115 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lindbom, A.G. Ljungman, M. Lindahl, and C. Tagesson Expression of members of the phospholipase A2 family of enzymes in human nasal mucosa Eur. Respir. J., July 1, 2001; 18(1): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Toward and K. J. Broadley Chronic Lipopolysaccharide Exposure on Airway Function, Cell Infiltration, and Nitric Oxide Generation in Conscious Guinea Pigs: Effect of Rolipram and Dexamethasone J. Pharmacol. Exp. Ther., July 1, 2001; 298(1): 298 - 306. [Abstract] [Full Text]
|
|
|
|
|
|
S. J. Mundell, M. E. Olah, R. A. Panettieri Jr., J. L. Benovic, and R. B. Penn Regulation of G Protein-Coupled Receptor-Adenylyl Cyclase Responsiveness in Human Airway Smooth Muscle by Exogenous and Autocrine Adenosine Am. J. Respir. Cell Mol. Biol., February 1, 2001; 24(2): 155 - 163. [Abstract] [Full Text]
|
|
|
|
|
|
R. Ishimitsu, H. Nishimura, T. Yajima, T. Watase, H. Kawauchi, and Y. Yoshikai Overexpression of IL-15 In Vivo Enhances Tc1 Response, Which Inhibits Allergic Inflammation in a Murine Model of Asthma J. Immunol., February 1, 2001; 166(3): 1991 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. LIM, D. GRONEBERG, A. FISCHER, T. OATES, G. CARAMORI, W. MATTOS, I. ADCOCK, P. J. BARNES, and K. F. CHUNG Expression of Heme Oxygenase Isoenzymes 1 and 2 in Normal and Asthmatic Airways . Effect of Inhaled Corticosteroids Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1912 - 1918. [Abstract] [Full Text]
|
|
|
|
|
|
D. C. Underwood, R. R. Osborn, S. Bochnowicz, E. F. Webb, D. J. Rieman, J. C. Lee, A. M. Romanic, J. L. Adams, D. W. P. Hay, and D. E. Griswold SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung Am J Physiol Lung Cell Mol Physiol, November 1, 2000; 279(5): L895 - L902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. MAGHNI, R. TAHA, W. AFIF, Q. HAMID, and J. G. MARTIN Dichotomy between Neurokinin Receptor Actions in Modulating Allergic Airway Responses in an Animal Model of Helper T Cell Type 2 Cytokine-associated Inflammation Am. J. Respir. Crit. Care Med., September 1, 2000; 162(3): 1068 - 1074. [Abstract] [Full Text]
|
|
|
|
|
|
P G Holt and P D Sly Paediatric origins of adult lung diseases bullet 2: Prevention of adult asthma by early intervention during childhood: potential value of new generation immunomodulatory drugs Thorax, August 1, 2000; 55(8): 700 - 703. [Full Text]
|
|
|
|
|
|
D. C. Underwood, R. R. Osborn, C. J. Kotzer, J. L. Adams, J. C. Lee, E. F. Webb, D. C. Carpenter, S. Bochnowicz, H. C. Thomas, D. W. P. Hay, et al. SB 239063, a Potent p38 MAP Kinase Inhibitor, Reduces Inflammatory Cytokine Production, Airways Eosinophil Infiltration, and Persistence J. Pharmacol. Exp. Ther., April 1, 2000; 293(1): 281 - 288. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. BARNES Endogenous Inhibitory Mechanisms in Asthma Am. J. Respir. Crit. Care Med., March 1, 2000; 161(3): S176 - 181. [Full Text] [PDF]
|
|
|
|
|
|
P. J. Barnes Mechanisms in COPD : Differences From Asthma Chest, February 1, 2000; 117(2_suppl): 10S - 14S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Nightingale, D. F Rogers, and P. J Barnes Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects Thorax, December 1, 1999; 54(12): 1061 - 1069. [Abstract] [Full Text]
|
|
|
|
|
|
P. J. BARNES Novel Approaches and Targets for Treatment of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., November 1, 1999; 160(5): S72 - 79. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
 |
 |
 |
|
 |
 |
 |
