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Vol. 51, Issue 1, 63-82, March 1999

Neurosteroids: Expression of Steroidogenic Enzymes and Regulation of Steroid Biosynthesis in the Central Nervous System

Ayikoe G. Mensah-Nyagan1, Jean-Luc Do-Rego, Delphine Beaujean, Van Luu-The, Georges Pelletier and Hubert Vaudry1

Institut Fédératif de Recherches Multidisciplinaires sur Les Peptides no. 23, Laboratoire de Neuroendocrinologie Cellulaire et Moléculaire, Institut National de la Santé et de la Recherche Médicale U 413, UA Centre National de la Recherche Scientifique, Université de Rouen, Mont-Saint-Aignan, France (A.G.M.-N., J.-L.D.-R., D.B., H.V.); and Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier de l'Université Laval, Quebec, Canada (V.L.-T., G.P.)

I. Introduction
II. Biochemical Pathways of Steroid Biosynthesis in Endocrine Glands
III. Cytochrome P-450scc
IV. 3beta -Hydroxysteroid Dehydrogenase
V. Cytochrome P-450c17
VI. 17beta -Hydroxysteroid Dehydrogenase
VII. 5alpha -Reductase
VIII. Aromatase
IX. Sulfotransferase and Sulfatase
X. 11beta -Hydroxysteroid Dehydrogenase
XI. Cytochrome P-45011beta
XII. Other Enzymes Involved in the Synthesis or Metabolism of Steroids
    A. 3alpha -Hydroxysteroid Dehydrogenase
    B. Delta 5-3beta -Hydroxysteroid Acyltransferase
    C. 7alpha -Hydroxylase
    D. Cytochrome P-450-Aldosterone Synthase
XIII. Conclusion and Clinical Implications
XIV. Summary
Acknowledgments
References

1   Address for correspondence: Dr. Hubert Vaudry, European Institute for Peptide Research (IFRMP no. 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U 413, UA CNRS, University of Rouen, 76821 Mont-Saint-Aignan, France. E-mail: hubert.vaudry{at}univ-rouen.fr

0031-6997/99/5101-0063$03.00/0
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Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics


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