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Vol. 51, Issue 2, 213-340, June 1999
Thoracic Medicine, Imperial College School of Medicine at the
National Heart & Lung Institute, London, United Kingdom
I. Introduction and Historical Perspective
II. Gross Morphology and Ultrastructure
III. Life Cycle, Maturation, and Tissue Distribution
IV. Transcription Factors and Eosinophilia
V. G Protein-Coupled Receptors and Their Ligands
A. Platelet-Activating Factor
1. Receptors and Signaling.
2. In Vitro Effects.
3. In Vivo Effects.
B. Leukotriene B4
1. Receptors and Signaling.
2. In Vivo Effects.
C. Cysteinyl Leukotrienes
1. In Vitro Effects.
2. In Vivo Effects.
D. N-Formyl-Methionyl-Leucyl-Phenylalanine
E. Chemokines
1. CC Chemokines.
2. CXC Chemokines.
F. Complement
1. Complement 3a Anaphylatoxin.
2. Complement 4a Anaphylatoxin.
3. Complement 5a Anaphylatoxin.
G. 5-Oxoeicosatetraenoic Acid (ETE), Hydroxyeicosatetraenoic Acids
(HETEs), and Dihydroxyeicosatetraenoic Acids (diHETEs)
H. Sensory Neuropeptides
1. Substance P.
2. CGRP.
3. Secretoneurin.
4. Vasoactive Intestinal Peptide.
I. Bradykinin
J. Endothelin
K. Adenosine
L. Histamine
M. Prostanoids
N. 
Adrenoceptors
O. 
Adrenoceptors
1. Receptors.
2. Activation of the NADPH Oxidase.
3. Degranulation.
4. Chemotaxis and Chemokinesis.
5. Adhesion and Adhesion Molecule Expression.
6. Membrane Lipid Metabolism.
7. Homotypic Aggregation.
8. In Vivo Effects.
P. Somatostatin
Q. Lipoxins
VI. Interleukin-3, Interleukin-5, and Granulocyte/Macrophage
Colony-Stimulating Factor
A. Receptor Expression and Regulation
B. Signal Transduction
C. Functional Effects
VII. Interferon Receptor Superfamily
VIII. Tumor Necrosis Factor Superfamily
A. Tumor Necrosis Factor
B. CD30 Ligand
C. CD40 and CD40 Ligand
D. CD69
E. CD95
F. Nerve Growth Factor
IX. Adhesion Molecules
A. Selectins
B. Integrins
1. 1 Integrins.
2. 2 Integrins.
3. 47 Integrin.
C. Intercellular Adhesion Molecule 1
X. Immunoglobulins
A. Receptors for Fc
B. Receptors for Fc
and Fcµ
C. Receptors for Fc
D. Receptors for Fc
XI. Miscellaneous
A. Interleukin-1
B. Interleukin-2
C. Interleukin-4
D. Interleukin-10
E. Interleukin-12
F. Interleukin-13
G. Transforming Growth Factor
H. Platelet-Derived Growth Factor
I. Stem Cell Factor
J. CD4
K. CD9
L. CD44
M. CD52
N. Complement Receptors Not Coupled Through G Proteins
1. CR1.
2. CR3.
3. CR4.
4. The C1q Receptor.
O. Melittin
P. Secretory Component
Q. Human Leukocyte Antigen
XII. Functional Consequences of Eosinophil Activation
A. Locomotion
1. Rolling.
2. Adhesion.
3. Transmigration and Chemotaxis.
B. Cytolysis, Secretion, and Piecemeal Degranulation
1. Granule Proteins
2. Morphological Changes
3. Cell-Signaling Events.
4. Electrophysiological Changes.
C. Generation of Lipid Mediators
1. Platelet-Activating Factor.
2. Cyclooxygenase Products.
3. 5-Lipoxygenase Products.
4. 12-Lipoxygenase Products.
5. 15-Lipoxygenase Products.
6. Lipoxins.
7. Lipid Bodies as Sites of Eicosanoid Formation.
D. Generation of Cytokines
1. Interleukin-1.
2. Interleukin-2.
3. Interleukin-3.
4. Interleukin-4.
5. Interleukin-5.
6. Interleukin-6.
7. Interleukin-10.
8. Interleukin-12.
9. Interleukin-16.
10. Interferon-.
11. Tumor Necrosis Factor .
12. Granulocyte/Macrophage Colony-Stimulating
Factor.
13. Macrophage Migration Inhibitory Factor.
E. Generation of Chemokines
1. Interleukin-8.
2. Macrophage Inflammatory Protein 1.
3. RANTES.
4. Eotaxin.
F. Generation of Growth Factors
1. Transforming Growth Factor .
2. Transforming Growth Factor 1.
3. Platelet-Derived Growth Factor.
4. Heparin-Binding, Epidermal Growth Factor-Like Growth
Factor.
5. Vascular Endothelial Growth Factor.
6. Nerve Growth Factor.
G. Activation of the NADPH Oxidase
H. Apoptosis
XIII. Eosinophil Heterogeneity
A. Physical Heterogeneity
B. Functional Heterogeneity
1. Cell-Cell Interactions.
2. Up-Regulation of Cell Surface Receptors.
C. Morphological Heterogeneity
D. Acquisition of a Hypodense Phenotype
XIV. Pharmacological Modulation of Eosinophil Function
A. Phosphodiesterase Inhibitors
1. Enzymology.
2. Activation of the NADPH Oxidase.
3. Degranulation.
4. Adhesion and Adhesion Molecule Expression.
5. Chemotaxis and Chemokinesis.
6. Synthesis of Lipid Mediators.
7. Apoptosis.
8. In Vivo Effects.
B. Theophylline
1. In Vitro Effects.
2. In Vivo Effects.
C. Cholera Toxin and Forskolin
D. Cyclic Nucleotide Analogs
E. Glucocorticosteroids
1. Receptors.
2. Maturation.
3. Adhesion and Adhesion Molecule Expression.
4. Cell Survival and Apoptosis.
5. Degranulation.
6. Chemotaxis.
7. Effects on Transcription of Genes Relevant to Eosinophil
Function.
8. Activation of the NADPH Oxidase.
9. Antigen Presentation.
F. Estrogen
G. Lazaroids
H. Retinoids
I. Cromones
J. Loop Diuretics
K. Sodium Channel-Blocking Drugs
L. Ketotifen
M. Cyclosporin A, Tacrolimus, and Rapamycin
1. In Vitro Effects.
2. In Vivo Effects.
N. Nitric Oxide
1. Apoptosis.
2. Chemotaxis.
3. In Vivo Effects.
O. Cetirizine and Other Second-Generation Histamine H1
Receptor Antagonists
XV. Concluding Remarks
Acknowledgments
References
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
A. Klein, A. Talvani, P. M. R. Silva, M. A. Martins, T. N. C. Wells, A. Proudfoot, N. W. Luckacs, and M. M. Teixeira Stem Cell Factor-Induced Leukotriene B4 Production Cooperates with Eotaxin to Mediate the Recruitment of Eosinophils During Allergic Pleurisy in Mice J. Immunol., July 1, 2001; 167(1): 524 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J S Erjefält, L Greiff, M Andersson, E Ädelroth, P K Jeffery, and C G A Persson Degranulation patterns of eosinophil granulocytes as determinants of eosinophil driven disease Thorax, May 1, 2001; 56(5): 341 - 344. [Abstract] [Full Text]
|
|
|
|
|
|
H. IIJIMA, A. DUGUET, S.-Y. EUM, Q. HAMID, and D. H. EIDELMAN Nitric Oxide and Protein Nitration are Eosinophil Dependent in Allergen-Challenged Mice Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1233 - 1240. [Abstract] [Full Text]
|
|
|
|
|
|
J. Van Wauwe, F. Aerts, M. Cools, F. Deroose, E. Freyne, J. Goossens, B. Hermans, J. Lacrampe, H. Van Genechten, F. Van Gerven, et al. Identification of R146225 as a Novel, Orally Active Inhibitor of Interleukin-5 Biosynthesis J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 655 - 661. [Abstract] [Full Text]
|
|
|
|
|
|
R. Newton Molecular mechanisms of glucocorticoid action: what is important? Thorax, July 1, 2000; 55(7): 603 - 613. [Full Text]
|
|
|
|
|
|
J. S. ERJEFÄLT and C. G. A. PERSSON New Aspects of Degranulation and Fates of Airway Mucosal Eosinophils Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 2074 - 2085. [Full Text]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
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|
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|
|
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