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Vol. 51, Issue 3, 533-591, September 1999
Department of Psychiatry, Neurobiological Psychiatry Unit, McGill
University, Montreal, Quebec, Canada
I. Introduction
II. Morphological Aspects of the 5-HT Rostral System
A. 5-HT Nuclei
1. The Caudal Linear Nucleus.
2. The Dorsal Raphe Nucleus.
3. The Median Raphe Nucleus.
4. The Supralemniscal Region.
B. Ultrastructure
1. Sources of Extracellular 5-HT in Rostral Raphe
Nuclei
2. Cell Bodies Found in the 5-HT Nuclei.
C. Afferents to Midbrain 5-HT Nuclei
D. Efferent Pathways and Terminal Projection Areas
1. Efferent Pathways.
2. Terminal Projection Areas.
III. Physiological and Pharmacological Aspects of the 5-HT System
A. Firing Activity of 5-HT Neurons
1. Autoregulation of 5-HT Neuron Firing Activity.
2. Role of Non-5-HT Receptors in the Regulation of 5-HT Neuron
Firing Activity.
3. Heteroregulation of 5-HT Neuron Firing Activity.
B. Effect of Antidepressant Drug Administration on 5-HT Neuron
Firing Activity
C. 5-HT Release
1. Neurotransmitter Release and Its Regulation: Cellular and
Molecular Aspects.
2. Physiological Role of Extracellular 5-HT Bioavailability in
Midbrain Raphe Nuclei.
3. Autoregulation of 5-HT Release in the Raphe Nuclei.
4. Heteroregulation of Neurotransmitter Release in Midbrain Raphe
Nuclei.
5. Autoregulation of 5-HT Release in Terminal Projection Areas:
Cortex and Hippocampus.
6. Heteroregulation of Neurotransmitter Release from 5-HT Fibers in
Cortex and Hippocampus.
7. 5-HT1B versus 5-HT1D Receptors.
D. Effect of Antidepressant Drug Administration on 5-HT Release
1. Administration of 5-HT Reuptake Blockers.
2. Prolonged Administration of MAOIs.
3. Antidepressants with 
2 Adrenoceptor Antagonistic
Properties.
4. Activation of 5-HT1A Receptors by
5-HT1A Agonists.
E. 5-HT Reuptake
1. Molecular Characteristics of the 5-HT Transporter (SERT).
2. The Mechanism of 5-HT Uptake.
3. Anatomical and Cellular Localization of the SERT.
4. Pharmacological Properties of the SERT.
5. Tianeptine, a Class by Itself?
F. Regulation of 5-HT Uptake Activity by Antidepressant Drugs
IV. Concluding Remarks
Acknowledgments
References
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