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Vol. 51, Issue 4, 651-690, December 1999
Institute of Pharmacology and Toxicology, University of
Halle-Wittenberg, Halle, Germany (O.-E.B.); and Department of Medicine,
University of Essen, Germany (M.C.M.)
I. Introduction
II. Presence and Function of Receptor Subtypes in Human Heart
A. 
1-Adrenoceptors
B. 2-Adrenoceptors
C. 
-Adrenoceptors
1. 1- and 2-Adrenoceptors.
2. Is There a Third (or Fourth) -Adrenoceptor Subtype Present in
Human Heart?
D. Muscarinic Acetylcholine Receptors
1. Muscarinic M2 Receptors.
2. Is There Another Muscarinic, Non-M2 Receptor in
Human Heart?
III. Autonomic Responsiveness in the Aging Human Heart
A. -Adrenoceptors
B. Muscarinic Receptors
IV. Autonomic Responsiveness in the Failing Human Heart
A. 1-Adrenoceptors
B. -Adrenoceptors
C. Muscarinic Receptors
D. Possible Mechanisms of Beneficial Effects of -Blockers in
Patients with Chronic Heart Failure
E. Lessons from Transgenic Animals
V. Receptor Polymorphisms
VI. Conclusions
Acknowledgments
References
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F. Lin, W. A. Owens, S. Chen, M. E. Stevens, S. Kesteven, J. F. Arthur, E. A. Woodcock, M. P. Feneley, and R. M. Graham Targeted {alpha}1A-Adrenergic Receptor Overexpression Induces Enhanced Cardiac Contractility but not Hypertrophy Circ. Res., August 17, 2001; 89(4): 343 - 350. [Abstract] [Full Text] [PDF]
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