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Vol. 51, Issue 4, 651-690, December 1999

Adrenergic and Muscarinic Receptors in the Human Heart

Otto-Erich Brodde1 and Martin C. Michel

Institute of Pharmacology and Toxicology, University of Halle-Wittenberg, Halle, Germany (O.-E.B.); and Department of Medicine, University of Essen, Germany (M.C.M.)

I. Introduction
II. Presence and Function of Receptor Subtypes in Human Heart
    A. alpha 1-Adrenoceptors
    B. alpha 2-Adrenoceptors
    C. beta -Adrenoceptors
        1. beta 1- and beta 2-Adrenoceptors.
        2. Is There a Third (or Fourth) beta -Adrenoceptor Subtype Present in Human Heart?
    D. Muscarinic Acetylcholine Receptors
        1. Muscarinic M2 Receptors.
        2. Is There Another Muscarinic, Non-M2 Receptor in Human Heart?
III. Autonomic Responsiveness in the Aging Human Heart
    A. beta -Adrenoceptors
    B. Muscarinic Receptors
IV. Autonomic Responsiveness in the Failing Human Heart
    A. alpha 1-Adrenoceptors
    B. beta -Adrenoceptors
    C. Muscarinic Receptors
    D. Possible Mechanisms of Beneficial Effects of beta -Blockers in Patients with Chronic Heart Failure
    E. Lessons from Transgenic Animals
V. Receptor Polymorphisms
VI. Conclusions
Acknowledgments
References


1 Address for correspondence: Otto-Erich Brodde, Ph.D., Institute of Pharmacology and Toxicology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse 4, D-06097 Halle/Saale, Germany.


0031-6997/99/5104-0651$03.00/0
PHARMACOLOGICAL REVIEWS
Copyright © 1999 by The American Society for Pharmacology and Experimental Therapeutics



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J.-M. Goaillard, P. Vincent, and R. Fischmeister
Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes
J. Physiol., January 1, 2001; 530(1): 79 - 91.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
A. Sabri, E. Pak, S. A. Alcott, B. A. Wilson, and S. F. Steinberg
Coupling Function of Endogenous {alpha}1- and {beta}-Adrenergic Receptors in Mouse Cardiomyocytes
Circ. Res., May 26, 2000; 86(10): 1047 - 1053.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
T. Meyer, M.-C. Wellner-Kienitz, A. Biewald, K. Bender, A. Eickel, and L. Pott
Depletion of Phosphatidylinositol 4,5-Bisphosphate by Activation of Phospholipase C-coupled Receptors Causes Slow Inhibition but Not Desensitization of G Protein-gated Inward Rectifier K+ Current in Atrial Myocytes
J. Biol. Chem., February 16, 2001; 276(8): 5650 - 5658.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
N. Nanda, S. E. Iismaa, W. A. Owens, A. Husain, F. Mackay, and R. M. Graham
Targeted Inactivation of Gh/Tissue Transglutaminase II
J. Biol. Chem., June 1, 2001; 276(23): 20673 - 20678.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. M. Small, K. M. Brown, S. L. Forbes, and S. B. Liggett
Modification of the beta 2-Adrenergic Receptor to Engineer a Receptor-Effector Complex for Gene Therapy
J. Biol. Chem., August 17, 2001; 276(34): 31596 - 31601.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M.-C. Wellner-Kienitz, K. Bender, and L. Pott
Overexpression of beta 1 and beta 2 Adrenergic Receptors in Rat Atrial Myocytes. DIFFERENTIAL COUPLING TO G PROTEIN-GATED INWARD RECTIFIER K+ CHANNELS VIA Gs AND Gi/o
J. Biol. Chem., September 28, 2001; 276(40): 37347 - 37354.
[Abstract] [Full Text] [PDF]


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Circ. Res.Home page
F. Lin, W. A. Owens, S. Chen, M. E. Stevens, S. Kesteven, J. F. Arthur, E. A. Woodcock, M. P. Feneley, and R. M. Graham
Targeted {alpha}1A-Adrenergic Receptor Overexpression Induces Enhanced Cardiac Contractility but not Hypertrophy
Circ. Res., August 17, 2001; 89(4): 343 - 350.
[Abstract] [Full Text] [PDF]




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