Pharmacological Reviews Get Tables of Contents delivered automatically
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Touyz, R. M.
Right arrow Articles by Schiffrin, E. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Touyz, R. M.
Right arrow Articles by Schiffrin, E. L.

Vol. 52, Issue 4, 639-672, December 2000

Signal Transduction Mechanisms Mediating the Physiological and Pathophysiological Actions of Angiotensin II in Vascular Smooth Muscle Cells

Rhian M. Touyz1 and Ernesto L. Schiffrin

Medical Research Council of Canada Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada

I. Introduction
II. Physiological Actions of Angiotensin II in Vascular Smooth Muscle Cells
    A. The Renin Angiotensin System---Production of Angiotensin II
    B. Angiotensin Receptors
    C. Vascular Actions of Angiotensin II
    D. Angiotensin II-Dependent Signaling Pathways
    E. Immediate Signaling Events Stimulated by Angiotensin II
        1. Stimulation of Phospholipase C and Phosphatidylinositol Hydrolysis.
        2. Increased Intracellular Free Calcium Concentration.
        3. Activation of Protein Kinase C.
        4. Stimulation of Na+/H+ Exchange.
        5. Angiotensin II Increases Intracellular Free Concentrations of Na+ and Decreases Intracellular Free Concentrations of Mg2+.
        6. Activation of Src Family Kinases.
    F. Early Signaling Events Mediated by Angiotensin II
        1. Activation of Tyrosine Kinases.
            a. Janus family kinases.
            b. Focal adhesion kinase and proline-rich tyrosine kinase 2.
            c. p130Cas.
            d. Phosphatidylinositol 3-kinase.
        2. Mitogen-Activated Protein Kinase Pathways.
            a. Upstream events.
            b. Downstream events.
            c. Angiotensin II and the mitogen-activated protein kinase pathway in cardiovascular cells.
        3. Activation of Phospholipase A2 and Arachidonic Acid Metabolism.
        4. Phospholipase D activation.
        5. Angiotensin II Effects on Cyclic Nucleotides.
    G. Long-Term Effects Mediated by Angiotensin II
        1. Generation of Reactive Oxygen Species.
        2. Angiotensin II-Induced Expression of Proto-Oncogenes and Growth Factors.
    H. Why the Special Role for Angiotensin II Signaling in Vascular Smooth Muscle Cells?
II. Altered Angiotensin II Signaling in Vascular Smooth Muscle Cells in Cardiovascular Diseases---Special Reference to Hypertension
    A. Introduction
    B. Vascular Changes
    C. Vascular Angiotensin Receptors
    D. Short-Term Signaling Events
        1. Angiotensin II Stimulation of the Phospholipase C-IP3-Diacylglycerol Pathway Is Augmented.
        2. Angiotensin II-Stimulated Effects on Vascular [Mg2+]i and [Na+]i.
        3. Vascular Eicosanoids, Angiotensin II, and Hypertension.
        4. Angiotensin II Increases Activity of Phospholipase D.
        5. Cyclic Nucleotides and Angiotensin II.
    E. Long-Term Signaling Events
        1. Angiotensin II-Induced Generation of Reactive Oxygen Species.
        2. Angiotensin II, Tyrosine Kinases, and Hypertension.
        3. Angiotensin II-Mediated Mitogen-Activated Protein Kinase Signaling Is Increased.
        4. Indirect Effects of Angiotensin II on the Vasculature.
    F. Mechanisms Underlying Enhanced Angiotensin II Vascular Responsiveness
IV. Conclusions
Acknowledgment
References

Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II (Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways, where intracellular targets of the phospholipase C-diacylglycerol-Ca2+ axis were distinct from those of the tyrosine kinase- and mitogen-activated protein kinase- dependent pathways. However, these major intracellular signaling cascades do not function independently and are actively engaged in cross-talk. Downstream signals from the Ang II-bound receptors converge to elicit complex and multiple responses. The exact adapter proteins or "go-between" molecules that link the multiple intracellular pathways await clarification. Ang II induces a multitude of actions in various tissues, and the signaling events following occupancy and activation of angiotensin receptors are tightly controlled and extremely complex. Alterations of these highly regulated signaling pathways in vascular smooth cells may be pivotal in structural and functional abnormalities that underlie vascular pathological processes in cardiovascular diseases such as hypertension, atherosclerosis, and post-interventional restenosis.

1 Address for correspondence: R. M. Touyz, M.D., Ph.D., Clinical Research Institute of Montreal, 110 Pine Ave. West, Montreal, Quebec H2W 1R7 Canada. E-mail: touyzr{at}ircm.qc.ca

0031-6997/00/5204-0639$03.00/0
PHARMACOLOGICAL REVIEWS
Copyright © 2000 by The American Society for Pharmacology and Experimental Therapeutics


This article has been cited by other articles:


Home page
 EndocrinologyHome page
H. Ohtsu, S. Higuchi, H. Shirai, K. Eguchi, H. Suzuki, A. Hinoki, E. Brailoiu, A. D. Eckhart, G. D. Frank, and S. Eguchi
Central Role of Gq in the Hypertrophic Signal Transduction of Angiotensin II in Vascular Smooth Muscle Cells
Endocrinology, July 1, 2008; 149(7): 3569 - 3575.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
R. Miyazaki, T. Ichiki, T. Hashimoto, K. Inanaga, I. Imayama, J. Sadoshima, and K. Sunagawa
SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol., July 1, 2008; 28(7): 1263 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Zeng, V. A. M. Villar, G. M. Eisner, S. M. Williams, R. A. Felder, and P. A. Jose
G Protein-Coupled Receptor Kinase 4: Role in Blood Pressure Regulation
Hypertension, June 1, 2008; 51(6): 1449 - 1455.
[Full Text] [PDF]

Home page
 J EndocrinolHome page
F. Xiao, J. R Puddefoot, S. Barker, and G. P Vinson
Changes in angiotensin II type 1 receptor signalling pathways evoked by a monoclonal antibody raised to the N-terminus
J. Endocrinol., April 1, 2008; 197(1): 25 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. C. Sullivan
Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1220 - R1226.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. Xiao, Z. Xu, X. Huang, L. D. Longo, S. Yang, and L. Zhang
Prenatal Gender-Related Nicotine Exposure Increases Blood Pressure Response to Angiotensin II in Adult Offspring
Hypertension, April 1, 2008; 51(4): 1239 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. L. Schiffrin
New Twist to the Role of the Renin-Angiotensin System in Heart Failure: Aldosterone Upregulates Renin-Angiotensin System Components in the Brain
Hypertension, March 1, 2008; 51(3): 622 - 623.
[Full Text] [PDF]

Home page
 Cardiovasc ResHome page
Q. Zhang, F. He, R. Kuruba, X. Gao, A. Wilson, J. Li, T. R. Billiar, B. R. Pitt, W. Xie, and S. Li
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells
Cardiovasc Res, February 1, 2008; 77(3): 560 - 569.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Nakashima, G. D. Frank, H. Shirai, A. Hinoki, S. Higuchi, H. Ohtsu, K. Eguchi, A. Sanjay, M. E. Reyland, P. J. Dempsey, et al.
Novel Role of Protein Kinase C-{delta} Tyr311 Phosphorylation in Vascular Smooth Muscle Cell Hypertrophy by Angiotensin II
Hypertension, February 1, 2008; 51(2): 232 - 238.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Yogi, C. Mercure, J. Touyz, G. E. Callera, A. C.I. Montezano, A. B. Aranha, R. C. Tostes, T. Reudelhuber, and R. M. Touyz
Renal Redox-Sensitive Signaling, but Not Blood Pressure, Is Attenuated by Nox1 Knockout in Angiotensin II-Dependent Chronic Hypertension
Hypertension, February 1, 2008; 51(2): 500 - 506.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Ceriello
Possible Role of Oxidative Stress in the Pathogenesis of Hypertension
Diabetes Care, February 1, 2008; 31(Supplement_2): S181 - S184.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Choi, T. L. Leto, L. Hunyady, K. J. Catt, Y. S. Bae, and S. G. Rhee
Mechanism of Angiotensin II-induced Superoxide Production in Cells Reconstituted with Angiotensin Type 1 Receptor and the Components of NADPH Oxidase
J. Biol. Chem., January 4, 2008; 283(1): 255 - 267.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. M. Stewart, I. Taneja, J. Glover, and M. S. Medow
Angiotensin II type 1 receptor blockade corrects cutaneous nitric oxide deficit in postural tachycardia syndrome
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H466 - H473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. Mendez-Bolaina, J. Sanchez-Gonzalez, I. Ramirez-Sanchez, E. Ocharan-Hernandez, M. Nunez-Sanchez, E. Meaney-Mendiolea, A. Meaney, J. Asbun-Bojalil, A. Miliar-Garcia, I. Olivares-Corichi, et al.
Effect of caveolin-1 scaffolding peptide and 17 -estradiol on intracellular Ca2+ kinetics evoked by angiotensin II in human vascular smooth muscle cells
Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1953 - C1961.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
W. O. Sampaio, C. Henrique de Castro, R. A.S. Santos, E. L. Schiffrin, and R. M. Touyz
Angiotensin-(1-7) Counterregulates Angiotensin II Signaling in Human Endothelial Cells
Hypertension, December 1, 2007; 50(6): 1093 - 1098.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. J. Casal, S. Ryser, A. M. Capponi, and C. F. Wang-Buholzer
Angiotensin II-Induced Mitogen-Activated Protein Kinase Phosphatase-1 Expression in Bovine Adrenal Glomerulosa Cells: Implications in Mineralocorticoid Biosynthesis
Endocrinology, November 1, 2007; 148(11): 5573 - 5581.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. J. Welch, K. Patel, P. Modlinger, M. Mendonca, N. Kawada, K. Dennehy, S. Aslam, and C. S. Wilcox
Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2644 - H2649.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G.-X. Zhang, X.-M. Lu, S. Kimura, and A. Nishiyama
Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation
Cardiovasc Res, November 1, 2007; 76(2): 204 - 212.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. J. Sampson, L. M. Davies, R. Barrett-Jolley, N. B. Standen, and C. Dart
Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels
Cardiovasc Res, October 1, 2007; 76(1): 61 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
H. Kobori, M. Nangaku, L. G. Navar, and A. Nishiyama
The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease
Pharmacol. Rev., September 1, 2007; 59(3): 251 - 287.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Yogi, G.E. Callera, A.C.I. Montezano, A.B. Aranha, R.C. Tostes, E.L. Schiffrin, and R.M. Touyz
Endothelin-1, but not Ang II, Activates MAP Kinases Through c-Src-Independent Ras-Raf-Dependent Pathways in Vascular Smooth Muscle Cells
Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1960 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. Ishikawa, K. Ogawa, Y. Tokinaga, N. Uematsu, K. Mizumoto, and Y. Hatano
The Mechanism Behind the Inhibitory Effect of Isoflurane on Angiotensin II-Induced Vascular Contraction Is Different from That of Sevoflurane
Anesth. Analg., July 1, 2007; 105(1): 97 - 102.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Y. Sung, H. Guan, A. Czibula, A. R. King, K. Eder, E. Heath, S. K. Suvarna, S. K. Dower, A. G. Wilson, S. E. Francis, et al.
Human Tribbles-1 Controls Proliferation and Chemotaxis of Smooth Muscle Cells via MAPK Signaling Pathways
J. Biol. Chem., June 22, 2007; 282(25): 18379 - 18387.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. A. Yaghini, F. Li, and K. U. Malik
Expression and Mechanism of Spleen Tyrosine Kinase Activation by Angiotensin II and Its Implication in Protein Synthesis in Rat Vascular Smooth Muscle Cells
J. Biol. Chem., June 8, 2007; 282(23): 16878 - 16890.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
D. Ribatti, M. T. Conconi, and G. G. Nussdorfer
Nonclassic Endogenous Novel Regulators of Angiogenesis
Pharmacol. Rev., June 1, 2007; 59(2): 185 - 205.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
X. Yu, K. Murao, H. Imachi, W.-M. Cao, J. Li, K. Matsumoto, T. Nishiuchi, R. A.M. Ahmed, N. C.W. Wong, H. Kosaka, et al.
Regulation of Scavenger Receptor Class BI Gene Expression by Angiotensin II in Vascular Endothelial Cells
Hypertension, June 1, 2007; 49(6): 1378 - 1384.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Wang, I. Armando, L. D. Asico, C. Escano, X. Wang, Q. Lu, R. A. Felder, C. G. Schnackenberg, D. R. Sibley, G. M. Eisner, et al.
The elevated blood pressure of human GRK4{gamma} A142V transgenic mice is not associated with increased ROS production
Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2083 - H2092.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. A. Morinelli, J. R. Raymond, A. Baldys, Q. Yang, M.-h. Lee, L. Luttrell, and M. E. Ullian
Identification of a putative nuclear localization sequence within ANG II AT1A receptor associated with nuclear activation
Am J Physiol Cell Physiol, April 1, 2007; 292(4): C1398 - C1408.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Virdis, R. Colucci, M. Fornai, E. Duranti, C. Giannarelli, N. Bernardini, C. Segnani, C. Ippolito, L. Antonioli, C. Blandizzi, et al.
Cyclooxygenase-1 Is Involved in Endothelial Dysfunction of Mesenteric Small Arteries From Angiotensin II-Infused Mice
Hypertension, March 1, 2007; 49(3): 679 - 686.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. K. Mehta and K. K. Griendling
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C82 - C97.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Ozawa, H. Kobori, Y. Suzaki, and L. G. Navar
Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F330 - F339.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. Eder, D. Probst, C. Rosker, M. Poteser, H. Wolinski, S.D. Kohlwein, C. Romanin, and K. Groschner
Phospholipase C-dependent control of cardiac calcium homeostasis involves a TRPC3-NCX1 signaling complex
Cardiovasc Res, January 1, 2007; 73(1): 111 - 119.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. Suzuki, K. Eguchi, H. Ohtsu, S. Higuchi, S. Dhobale, G. D. Frank, E. D. Motley, and S. Eguchi
Activation of Endothelial Nitric Oxide Synthase by the Angiotensin II Type 1 Receptor
Endocrinology, December 1, 2006; 147(12): 5914 - 5920.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. N. Saleh, A. P. Albert, C. M. Peppiatt, and W. A. Large
Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes
J. Physiol., December 1, 2006; 577(2): 479 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
H. Okada, T. Inoue, T. Kikuta, Y. Watanabe, Y. Kanno, S. Ban, T. Sugaya, M. Horiuchi, and H. Suzuki
A Possible Anti-Inflammatory Role of Angiotensin II Type 2 Receptor in Immune-Mediated Glomerulonephritis during Type 1 Receptor Blockade
Am. J. Pathol., November 1, 2006; 169(5): 1577 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Yzydorczyk, F. Gobeil Jr., G. Cambonie, I. Lahaie, N. L. O. Le, S. Samarani, A. Ahmad, J. C. Lavoie, L. L. Oligny, P. Pladys, et al.
Exaggerated vasomotor response to ANG II in rats with fetal programming of hypertension associated with exposure to a low-protein diet during gestation
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R1060 - R1068.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Ohtsu, H. Suzuki, H. Nakashima, S. Dhobale, G. D. Frank, E. D. Motley, and S. Eguchi
Angiotensin II Signal Transduction Through Small GTP-Binding Proteins: Mechanism and Significance in Vascular Smooth Muscle Cells
Hypertension, October 1, 2006; 48(4): 534 - 540.
[Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Policha, N. Daneshtalab, L. Chen, L. B. Dale, C. Altier, H. Khosravani, W. G. Thomas, G. W. Zamponi, and S. S. G. Ferguson
Role of Angiotensin II Type 1A Receptor Phosphorylation, Phospholipase D, and Extracellular Calcium in Isoform-specific Protein Kinase C Membrane Translocation Responses
J. Biol. Chem., September 8, 2006; 281(36): 26340 - 26349.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
H. Ohtsu, P. J. Dempsey, G. D. Frank, E. Brailoiu, S. Higuchi, H. Suzuki, H. Nakashima, K. Eguchi, and S. Eguchi
ADAM17 Mediates Epidermal Growth Factor Receptor Transactivation and Vascular Smooth Muscle Cell Hypertrophy Induced by Angiotensin II
Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): e133 - e137.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
I. A. Arenas, S. J. Armstrong, Y. Xu, and S. T. Davidge
Tumor Necrosis Factor-{alpha} and Vascular Angiotensin II in Estrogen-Deficient Rats
Hypertension, September 1, 2006; 48(3): 497 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Ohtsu, P. J. Dempsey, and S. Eguchi
ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors
Am J Physiol Cell Physiol, July 1, 2006; 291(1): C1 - C10.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Hunyady and K. J. Catt
Pleiotropic AT1 Receptor Signaling Pathways Mediating Physiological and Pathogenic Actions of Angiotensin II
Mol. Endocrinol., May 1, 2006; 20(5): 953 - 970.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. P. Zankov, M. Omatsu-Kanbe, T. Isono, F. Toyoda, W.-G. Ding, H. Matsuura, and M. Horie
Angiotensin II Potentiates the Slow Component of Delayed Rectifier K+ Current via the AT1 Receptor in Guinea Pig Atrial Myocytes
Circulation, March 14, 2006; 113(10): 1278 - 1286.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
N. Ardanaz and P. J. Pagano
Hydrogen peroxide as a paracrine vascular mediator: regulation and signaling leading to dysfunction.
Experimental Biology and Medicine, March 1, 2006; 231(3): 237 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
Z. Ying, L. Jin, T. Palmer, and R. C. Webb
Angiotensin II Up-Regulates the Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (RhoGEF), a Regulator of G Protein Signaling Domain-Containing RhoGEF, in Vascular Smooth Muscle Cells
Mol. Pharmacol., March 1, 2006; 69(3): 932 - 940.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Benkirane, E. C. Viel, F. Amiri, and E. L. Schiffrin
Peroxisome Proliferator-Activated Receptor {gamma} Regulates Angiotensin II-Stimulated Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase in Blood Vessels In Vivo
Hypertension, January 1, 2006; 47(1): 102 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Pladys, F. Sennlaub, S. Brault, D. Checchin, I. Lahaie, N. L. O. Le, K. Bibeau, G. Cambonie, D. Abran, M. Brochu, et al.
Microvascular rarefaction and decreased angiogenesis in rats with fetal programming of hypertension associated with exposure to a low-protein diet in utero
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1580 - R1588.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. A. Woolfolk, S. Eguchi, H. Ohtsu, H. Nakashima, H. Ueno, W. T. Gerthoffer, and E. D. Motley
Angiotensin II-induced activation of p21-activated kinase 1 requires Ca2+ and protein kinase C{delta} in vascular smooth muscle cells
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1286 - C1294.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. De Ciuceis, F. Amiri, P. Brassard, D. H. Endemann, R. M. Touyz, and E. L. Schiffrin
Reduced Vascular Remodeling, Endothelial Dysfunction, and Oxidative Stress in Resistance Arteries of Angiotensin II-Infused Macrophage Colony-Stimulating Factor-Deficient Mice: Evidence for a Role in Inflammation in Angiotensin-Induced Vascular Injury
Arterioscler. Thromb. Vasc. Biol., October 1, 2005; 25(10): 2106 - 2113.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
H. Ohtsu, M. Mifune, G. D. Frank, S. Saito, T. Inagami, S. Kim-Mitsuyama, Y. Takuwa, T. Sasaki, J. D. Rothstein, H. Suzuki, et al.
Signal-Crosstalk Between Rho/ROCK and c-Jun NH2-Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II
Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1831 - 1836.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. Brassard, F. Amiri, and E. L. Schiffrin
Combined Angiotensin II Type 1 and Type 2 Receptor Blockade on Vascular Remodeling and Matrix Metalloproteinases in Resistance Arteries
Hypertension, September 1, 2005; 46(3): 598 - 606.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
J. Yu, K. Mizumoto, Y. Tokinaga, K. Ogawa, and Y. Hatano
The Inhibitory Effects of Sevoflurane on Angiotensin II- Induced, p44/42 Mitogen-Activated Protein Kinase-Mediated Contraction of Rat Aortic Smooth Muscle
Anesth. Analg., August 1, 2005; 101(2): 315 - 321.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Mifune, H. Ohtsu, H. Suzuki, H. Nakashima, E. Brailoiu, N. J. Dun, G. D. Frank, T. Inagami, S. Higashiyama, W. G. Thomas, et al.
G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding through Angiotensin II Type-1 Receptor
J. Biol. Chem., July 15, 2005; 280(28): 26592 - 26599.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
U. G. B. Haider, T. U. Roos, M. I. Kontaridis, B. G. Neel, D. Sorescu, K. K. Griendling, A. M. Vollmar, and V. M. Dirsch
Resveratrol Inhibits Angiotensin II- and Epidermal Growth Factor-Mediated Akt Activation: Role of Gab1 and Shp2
Mol. Pharmacol., July 1, 2005; 68(1): 41 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
R. M Touyz
Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II
Exp Physiol, July 1, 2005; 90(4): 449 - 455.
[Abstract] [Full Text] [PDF]