Pharmacological Reviews xPharm- The Comprehensive Pharmacology Reference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     


0031-6997/05/5702-279-288$7.00
Pharmacol Rev 57:279-288, 2005

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Foord, S. M.
Right arrow Articles by Harmar, A. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Foord, S. M.
Right arrow Articles by Harmar, A. J.

Article

International Union of Pharmacology. XLVI. G Protein-Coupled Receptor List

Steven M. Foord, Tom I. Bonner1, Richard R. Neubig, Edward M. Rosser, Jean-Phillipe Pin, Anthony P. Davenport, Michael Spedding and Anthony J. Harmar

GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, United Kingdom (S.M.F.); Laboratory of Genetics, National Institute of Mental Health, Bethesda, Maryland (T.I.B.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (R.R.N.); Division of Neuroscience and Centre for Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom (E.M.R., A.J.H.); Centre National de la Recherche Scientifique, Montpellier, France (J.-P.P.); Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom (A.P.D); and Institut de Recherches Servier (I.d.R.S.), Suresnes, France (M.S.)

Abstract
I. Introduction
II. The Scope of the International Union of Pharmacology Receptor List
III. Maintenance of the List
Abstract

NC-IUPHAR (International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification) and its subcommittees provide authoritative reports on the nomenclature and pharmacology of G protein-coupled receptors (GPCRs) that summarize their structure, pharmacology, and roles in physiology and pathology. These reports are published in Pharmacological Reviews (http://www.iuphar.org/nciuphar_arti.html) and through the International Union of Pharmacology (IUPHAR) Receptor Database web site (http://www.iuphar-db.org/iuphar-rd). The essentially complete sequencing of the human genome has allowed the cataloging of all of the human gene sequences potentially encoding GPCRs. The IUPHAR Receptor List (http://www.iuphar-db.org/iuphar-rd/list/index.htm) presents this catalog giving IUPHAR-approved nomenclature (where available), known ligands, and gene names for all of these potential receptors (excluding sensory receptors and pseudogenes) together with links to curated sequence, descriptive information, and additional links in the Entrez Gene database (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene). This list is a major new initiative of NC-IUPHAR that, through continuing curation, defines the target of our ongoing receptor classification and invites further input from the scientific community.

Address correspondence to: Steven M. Foord, GlaxoSmithKline Research and Development, Stevenage, Hertfordshire, UK. E-mail: smf3746{at}ggr.co.uk




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
A. Strasser, H.-J. Wittmann, and R. Seifert
Ligand-Specific Contribution of the N Terminus and E2-Loop to Pharmacological Properties of the Histamine H1-Receptor
J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 783 - 791.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. A. Artigas, A. Gonzalez, E. Riquelme, C. A. Carvajal, A. Cattani, A. Martinez-Aguayo, A. M. Kalergis, T. Perez-Acle, and C. E. Fardella
A Novel Adrenocorticotropin Receptor Mutation Alters Its Structure and Function, Causing Familial Glucocorticoid Deficiency
J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3097 - 3105.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. Dong, P. C.-H. Lam, D. I. Pinon, P. M. Sexton, R. Abagyan, and L. J. Miller
Spatial Approximation between Secretin Residue Five and the Third Extracellular Loop of Its Receptor Provides New Insight into the Molecular Basis of Natural Agonist Binding
Mol. Pharmacol., August 1, 2008; 74(2): 413 - 422.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Runge, H. Thogersen, K. Madsen, J. Lau, and R. Rudolph
Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain
J. Biol. Chem., April 25, 2008; 283(17): 11340 - 11347.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. Szidonya, M. Cserzo, and L. Hunyady
Dimerization and oligomerization of G-protein-coupled receptors: debated structures with established and emerging functions
J. Endocrinol., March 1, 2008; 196(3): 435 - 453.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. T.C.C. Patrao, D. B.C. Queiroz, G. Grossman, P. Petrusz, M. d. F. M. Lazari, and M. C. W. Avellar
Cloning, expression and immunolocalization of {alpha}1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract
Mol. Hum. Reprod., February 1, 2008; 14(2): 85 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Okuno, A. Tamon, H. Yabuuchi, S. Niijima, Y. Minowa, K. Tonomura, R. Kunimoto, and C. Feng
GLIDA: GPCR ligand database for chemical genomics drug discovery database and tools update
Nucleic Acids Res., January 11, 2008; 36(suppl_1): D907 - D912.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. F. Hamdan, M. D. Rochdi, B. Breton, D. Fessart, D. E. Michaud, P. G. Charest, S. A. Laporte, and M. Bouvier
Unraveling G Protein-coupled Receptor Endocytosis Pathways Using Real-time Monitoring of Agonist-promoted Interaction between beta-Arrestins and AP-2
J. Biol. Chem., October 5, 2007; 282(40): 29089 - 29100.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. H. Li, S.-J. Han, F. F. Hamdan, S.-K. Kim, K. A. Jacobson, L. M. Bloodworth, X. Zhang, and J. Wess
Distinct Structural Changes in a G Protein-coupled Receptor Caused by Different Classes of Agonist Ligands
J. Biol. Chem., September 7, 2007; 282(36): 26284 - 26293.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Parthier, M. Kleinschmidt, P. Neumann, R. Rudolph, S. Manhart, D. Schlenzig, J. Fanghanel, J.-U. Rahfeld, H.-U. Demuth, and M. T. Stubbs
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
PNAS, August 28, 2007; 104(35): 13942 - 13947.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
O. P. Ernst, V. Gramse, M. Kolbe, K. P. Hofmann, and M. Heck
Monomeric G protein-coupled receptor rhodopsin in solution activates its G protein transducin at the diffusion limit
PNAS, June 26, 2007; 104(26): 10859 - 10864.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Michalski, V. Michel, A. Bahloul, G. Lefevre, J. Barral, H. Yagi, S. Chardenoux, D. Weil, P. Martin, J.-P. Hardelin, et al.
Molecular Characterization of the Ankle-Link Complex in Cochlear Hair Cells and Its Role in the Hair Bundle Functioning
J. Neurosci., June 13, 2007; 27(24): 6478 - 6488.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
M. E. Bigal, R. B. Lipton, P. R. Holland, and P. J. Goadsby
Obesity, migraine, and chronic migraine: Possible mechanisms of interaction
Neurology, May 22, 2007; 68(21): 1851 - 1861.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Binet, B. Duthey, J. Lecaillon, C. Vol, J. Quoyer, G. Labesse, J.-P. Pin, and L. Prezeau
Common Structural Requirements for Heptahelical Domain Function in Class A and Class C G Protein-coupled Receptors
J. Biol. Chem., April 20, 2007; 282(16): 12154 - 12163.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
J. Bodenstein, R. K. Sunahara, and R. R. Neubig
N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells
Mol. Pharmacol., April 1, 2007; 71(4): 1040 - 1050.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Scarselli, B. Li, S.-K. Kim, and J. Wess
Multiple Residues in the Second Extracellular Loop Are Critical for M3 Muscarinic Acetylcholine Receptor Activation
J. Biol. Chem., March 9, 2007; 282(10): 7385 - 7396.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
J.-P. Pin, R. Neubig, M. Bouvier, L. Devi, M. Filizola, J. A. Javitch, M. J. Lohse, G. Milligan, K. Palczewski, M. Parmentier, et al.
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers
Pharmacol. Rev., March 1, 2007; 59(1): 5 - 13.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
B. Roozendaal, R. Lengvilas, J. L. McGaugh, O. Civelli, and R. K. Reinscheid
Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation
Learn. Mem., January 1, 2007; 14(1-2): 29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. Salom, D. T. Lodowski, R. E. Stenkamp, I. L. Trong, M. Golczak, B. Jastrzebska, T. Harris, J. A. Ballesteros, and K. Palczewski
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
PNAS, October 31, 2006; 103(44): 16123 - 16128.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. C. H. Ko, H. Wei, J. H. Woods, and R. T. Kennedy
Effects of Intrathecally Administered Nociceptin/Orphanin FQ in Monkeys: Behavioral and Mass Spectrometric Studies
J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1257 - 1264.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. J. Kleinz, J. J. Maguire, J. N. Skepper, and A. P. Davenport
Functional and immunocytochemical evidence for a role of ghrelin and des-octanoyl ghrelin in the regulation of vascular tone in man
Cardiovasc Res, January 1, 2006; 69(1): 227 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Mitsukawa, R. Yamamoto, S. Ofner, J. Nozulak, O. Pescott, S. Lukic, N. Stoehr, C. Mombereau, R. Kuhn, K. H. McAllister, et al.
From The Cover: A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo
PNAS, December 20, 2005; 102(51): 18712 - 18717.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. P. Davenport, T. I. Bonner, S. M. Foord, A. J. Harmar, R. R. Neubig, J.-P. Pin, M. Spedding, M. Kojima, and K. Kangawa
International Union of Pharmacology. LVI. Ghrelin Receptor Nomenclature, Distribution, and Function
Pharmacol. Rev., December 1, 2005; 57(4): 541 - 546.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition
Copyright © 2005 by the American Society for Pharmacology and Experimental Therapeutics