Review ArticleReview Article
Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application
Vindhya Koppaka, David C. Thompson, Ying Chen, Manuel Ellermann, Kyriacos C. Nicolaou, Risto O. Juvonen, Dennis Petersen, Richard A. Deitrich, Thomas D. Hurley and Vasilis Vasiliou
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews July 2012, 64 (3) 520-539; DOI: https://doi.org/10.1124/pr.111.005538
Vindhya Koppaka
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
David C. Thompson
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Ying Chen
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Manuel Ellermann
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Kyriacos C. Nicolaou
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Risto O. Juvonen
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Dennis Petersen
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Richard A. Deitrich
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Thomas D. Hurley
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Vasilis Vasiliou
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
David R. Sibley
Departments of Pharmaceutical Sciences (V.K., Y.C., D.P., V.V.) and Clinical Pharmacy (D.C.T.), School of Pharmacy, and Department of Pharmacology, School of Medicine (R.A.D.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Chemistry (M.E., K.C.N.) and Skaggs Institute of Chemical Biology (K.C.N.), the Scripps Research Institute, La Jolla, California; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California (K.C.N.); School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland (R.O.J.); and Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana (T.D.H.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
ALDEHYDE DEHYDROGENASE INHIBITORS
Vindhya Koppaka, David C. Thompson, Ying Chen, Manuel Ellermann, Kyriacos C. Nicolaou, Risto O. Juvonen, Dennis Petersen, Richard A. Deitrich, Thomas D. Hurley and Vasilis Vasiliou
Pharmacological Reviews July 1, 2012, 64 (3) 520-539; DOI: https://doi.org/10.1124/pr.111.005538
Review ArticleReview Article
ALDEHYDE DEHYDROGENASE INHIBITORS
Vindhya Koppaka, David C. Thompson, Ying Chen, Manuel Ellermann, Kyriacos C. Nicolaou, Risto O. Juvonen, Dennis Petersen, Richard A. Deitrich, Thomas D. Hurley and Vasilis Vasiliou
Pharmacological Reviews July 1, 2012, 64 (3) 520-539; DOI: https://doi.org/10.1124/pr.111.005538
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