Abstract
1. Gluconeogenesis from lactate in the perfused liver is stimulated by glucagon and the catecholamines. It is suggested that this effect has physiological significance.
2. The effect of the hormones on gluconeogenesis appears to be mediated by cyclic 3',5'-AMP.
3. The hormones (or cyclic 3',5'-AMP) activate more than one step in the pathway of lactate to glucose. The changes in the concentration of metabolic intermediates induced by the hormones are consistent with activations of phosphopyruvate carboxylase and the hexose phosphate phosphatases.
PharmRev articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.