Abstract
The endogenous catecholamine content in various tissues can be reduced as a consequence of inhibition of tyrosine hydroxylase, the first step in the biosynthetic pathway for NE synthesis. Chemical evidence is presented to confirm the inhibition of this step in vivo with α-MPT. Studies relating to the pharmacologic consequences of blockade of NE synthesis are presented as well as the possible application of inhibitors of the enzymatic synthesis of NE in elucidating the role of NE in various adrenergic functions.
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