About the cover: Regulation of β-adrenoceptor turnover via desensitization and sequestration mechanism. At the onset, the constitutively phosphorylated β-arrestin-1 is recruited by the agonist stimulation of the receptor, followed by its rapid dephosphorylation at the plasma membrane. This process transforms the β-arrestin-1 into a clathrin adaptor, which then controls the endocytotic process. The β-arrestin binds to the GRK-phophorylated β-AR bound to the Gs protein. The receptor is then sequestered to the endosomal compartment via clathrin-coated vesicles to be dephosphorylated and recycled back to the plasma membrane in the preligand exposed state. ARR, β-arrestin; H, hormone; G, heterotrimeric G protein; GRK, G-protein-coupled receptor kinase; GRP, G protein-coupled receptor phosphatase; P, inorganic phosphate group. See the article by Dzimiri on page 465 of this issue.