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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob and Neal L. Benowitz
Pharmacological Reviews March 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3
Janne Hukkanen
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Pleyton Jacob
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Neal L. Benowitz
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and the Departments of Medicine and Psychiatry, University of California, San Francisco, California
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Pharmacological Reviews: 57 (1)
Pharmacological Reviews
Vol. 57, Issue 1
1 Mar 2005
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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob and Neal L. Benowitz
Pharmacological Reviews March 1, 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3

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Research ArticleArticle

Metabolism and Disposition Kinetics of Nicotine

Janne Hukkanen, Pleyton Jacob and Neal L. Benowitz
Pharmacological Reviews March 1, 2005, 57 (1) 79-115; DOI: https://doi.org/10.1124/pr.57.1.3
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  • Article
    • Abstract
    • I. Introduction
    • II. Nicotine and Related Alkaloids in Tobacco Products
    • III. Absorption of Nicotine from Tobacco Smoke and Nicotine Medications
    • IV. Distribution of Nicotine in Body Tissues
    • V. Nicotine and Cotinine Blood Levels during Tobacco Use and Nicotine Replacement Therapy
    • VI. Metabolism of Nicotine
    • VII. Excretion
    • VIII. Species Differences in Nicotine Metabolism
    • IX. Metabolism of Minor Alkaloids of Tobacco
    • X. Pharmacokinetics and Metabolism of Nicotine Analogs
    • XI. Conclusions and Areas for Further Study
    • Acknowledgments
    • Footnotes
    • References
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