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Therapeutic Targets: Progress of Their Exploration and Investigation of Their Characteristics

C. J. Zheng, L. Y. Han, C. W. Yap, Z. L. Ji, Z. W. Cao and Y. Z. Chen
Pharmacological Reviews June 2006, 58 (2) 259-279; DOI: https://doi.org/10.1124/pr.58.2.4
C. J. Zheng
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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L. Y. Han
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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C. W. Yap
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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Z. L. Ji
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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Z. W. Cao
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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Y. Z. Chen
Bioinformatics and Drug Design Group, Department of Computational Science, National University of Singapore, Singapore, Singapore
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This article has a correction. Please see:

  • Correction to “Therapeutic Targets: Progress of Their Exploration and Investigation of Their Characteristics” - September 01, 2006

Abstract

Modern drug discovery is primarily based on the search and subsequent testing of drug candidates acting on a preselected therapeutic target. Progress in genomics, protein structure, proteomics, and disease mechanisms has led to a growing interest in and effort for finding new targets and more effective exploration of existing targets. The number of reported targets of marketed and investigational drugs has significantly increased in the past 8 years. There are 1535 targets collected in the therapeutic target database compared with ∼500 targets reported in a 1996 review. Knowledge of these targets is helpful for molecular dissection of the mechanism of action of drugs and for predicting features that guide new drug design and the search for new targets. This article summarizes the progress of target exploration and investigates the characteristics of the currently explored targets to analyze their sequence, structure, family representation, pathway association, tissue distribution, and genome location features for finding clues useful for searching for new targets. Possible “rules” to guide the search for druggable proteins and the feasibility of using a statistical learning method for predicting druggable proteins directly from their sequences are discussed.

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Pharmacological Reviews: 58 (2)
Pharmacological Reviews
Vol. 58, Issue 2
1 Jun 2006
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Therapeutic Targets: Progress of Their Exploration and Investigation of Their Characteristics

C. J. Zheng, L. Y. Han, C. W. Yap, Z. L. Ji, Z. W. Cao and Y. Z. Chen
Pharmacological Reviews June 1, 2006, 58 (2) 259-279; DOI: https://doi.org/10.1124/pr.58.2.4

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OtherReview Article

Therapeutic Targets: Progress of Their Exploration and Investigation of Their Characteristics

C. J. Zheng, L. Y. Han, C. W. Yap, Z. L. Ji, Z. W. Cao and Y. Z. Chen
Pharmacological Reviews June 1, 2006, 58 (2) 259-279; DOI: https://doi.org/10.1124/pr.58.2.4
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  • Article
    • Abstract
    • I. Introduction
    • II. Distribution of Therapeutic Targets with Respect to Disease Classes
    • III. Current Trends in Exploration of Therapeutic Targets
    • IV. Characteristics of Therapeutic Targets
    • V. Can Druggable Proteins Be Predicted from Their Sequence?
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