Review ArticleReview Article
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
Tarek Boutros, Eric Chevet and Peter Metrakos
Pharmacological Reviews September 2008, 60 (3) 261-310; DOI: https://doi.org/10.1124/pr.107.00106
Tarek Boutros
Departments of Surgery (T.B., E.C., P.M.) and Anatomy and Cell Biology (T.B.), McGill University, Montreal, Quebec, Canada; Team Avenir, Institut National de la Santé et de la Recherche Médicale, U889, Bordeaux, France (E.C.); and Université Bordeaux 2, Bordeaux, France (E.C.)
Eric Chevet
Departments of Surgery (T.B., E.C., P.M.) and Anatomy and Cell Biology (T.B.), McGill University, Montreal, Quebec, Canada; Team Avenir, Institut National de la Santé et de la Recherche Médicale, U889, Bordeaux, France (E.C.); and Université Bordeaux 2, Bordeaux, France (E.C.)
Peter Metrakos
Departments of Surgery (T.B., E.C., P.M.) and Anatomy and Cell Biology (T.B.), McGill University, Montreal, Quebec, Canada; Team Avenir, Institut National de la Santé et de la Recherche Médicale, U889, Bordeaux, France (E.C.); and Université Bordeaux 2, Bordeaux, France (E.C.)
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Review ArticleReview Article
Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer
Tarek Boutros, Eric Chevet and Peter Metrakos
Pharmacological Reviews September 1, 2008, 60 (3) 261-310; DOI: https://doi.org/10.1124/pr.107.00106
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- Article
- Abstract
- I. Introduction
- II. Mitogen-Activated Protein Kinase Family: An Overview
- III. Regulation of Mitogen-Activated Protein Kinase Phosphatase-1 Expression and Activity
- IV. Overview of the Dual-Specificity Phosphatase Family
- V. Mitogen-Activated Protein Kinase Phosphatase-1, Animal Models, and Cancer
- VI. Mitogen-Activated Protein Kinase Phosphatase, Cancer in Humans, and Relevant Models
- VII. Conclusion
- Acknowledgments
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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