Review ArticleReview Article
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases
Brice Korkmaz, Marshall S. Horwitz, Dieter E. Jenne and Francis Gauthier
David Sibley, ASSOCIATE EDITOR
Pharmacological Reviews December 2010, 62 (4) 726-759; DOI: https://doi.org/10.1124/pr.110.002733
Brice Korkmaz
Institut National de la Santé et de la Recherche Médicale U-618 “Protéases et Vectorisation Pulmonaires,” Tours, France (B.K., F.G.); Université François Rabelais, Tours, France (B.K., F.G.); Department of Pathology, University of Washington, Seattle, Washington (M.S.H.); and Max-Planck Institute of Neurobiology, Martinsried, Germany (D.E.J.)
Marshall S. Horwitz
Institut National de la Santé et de la Recherche Médicale U-618 “Protéases et Vectorisation Pulmonaires,” Tours, France (B.K., F.G.); Université François Rabelais, Tours, France (B.K., F.G.); Department of Pathology, University of Washington, Seattle, Washington (M.S.H.); and Max-Planck Institute of Neurobiology, Martinsried, Germany (D.E.J.)
Dieter E. Jenne
Institut National de la Santé et de la Recherche Médicale U-618 “Protéases et Vectorisation Pulmonaires,” Tours, France (B.K., F.G.); Université François Rabelais, Tours, France (B.K., F.G.); Department of Pathology, University of Washington, Seattle, Washington (M.S.H.); and Max-Planck Institute of Neurobiology, Martinsried, Germany (D.E.J.)
Francis Gauthier
Institut National de la Santé et de la Recherche Médicale U-618 “Protéases et Vectorisation Pulmonaires,” Tours, France (B.K., F.G.); Université François Rabelais, Tours, France (B.K., F.G.); Department of Pathology, University of Washington, Seattle, Washington (M.S.H.); and Max-Planck Institute of Neurobiology, Martinsried, Germany (D.E.J.)
David Sibley
Institut National de la Santé et de la Recherche Médicale U-618 “Protéases et Vectorisation Pulmonaires,” Tours, France (B.K., F.G.); Université François Rabelais, Tours, France (B.K., F.G.); Department of Pathology, University of Washington, Seattle, Washington (M.S.H.); and Max-Planck Institute of Neurobiology, Martinsried, Germany (D.E.J.)
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases
Brice Korkmaz, Marshall S. Horwitz, Dieter E. Jenne and Francis Gauthier
Pharmacological Reviews December 1, 2010, 62 (4) 726-759; DOI: https://doi.org/10.1124/pr.110.002733
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- Article
- Abstract
- I. Introduction
- II. Neutrophil Elastase, Proteinase 3, and Cathepsin G
- III. Biological Functions of Elastase, Proteinase 3, and Cathepsin G
- IV. Physiological Inhibitors of Elastase, Proteinase 3, and Cathepsin G
- V. Pathophysiology of Elastase, Proteinase 3 and Cathepsin G in Human Diseases
- VI. New Strategies for Fighting Neutrophil Serine Protease-Related Human Diseases
- VII. Concluding Remarks
- Acknowledgments.
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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