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Review ArticleReview Article

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Teijo I. Saari, Mikko Uusi-Oukari, Jouni Ahonen and Klaus T. Olkkola
Markku Koulu, ASSOCIATE EDITOR
Pharmacological Reviews March 2011, 63 (1) 243-267; DOI: https://doi.org/10.1124/pr.110.002717
Teijo I. Saari
Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
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Mikko Uusi-Oukari
Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
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Jouni Ahonen
Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
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Klaus T. Olkkola
Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
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Markku Koulu
Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
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Article Information

vol. 63 no. 1 243-267
DOI 
https://doi.org/10.1124/pr.110.002717
PubMed 
21245208

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0031-6997
Online ISSN 
1521-0081
History 
  • Published online February 15, 2011.

Article Versions

  • Earlier version (January 18, 2011 - 07:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2011 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Teijo I. Saari,
  2. Mikko Uusi-Oukari,
  3. Jouni Ahonen, and
  4. Klaus T. Olkkola
  1. Departments of Anesthesiology, Intensive Care, Emergency Care, and Pain Medicine (T.I.S., K.T.O.) and Pharmacology, Drug Development and Therapeutics (M.U.-O.), University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland (T.I.S., K.T.O.); and Department of Anesthesia and Intensive Care Medicine, Helsinki University Hospital, Helsinki, Finland (J.A.)
  1. Markku Koulu, ASSOCIATE EDITOR
  1. Address correspondence to:
    Dr. Teijo I. Saari, Department of Anesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, P.O. Box 52 (Kiinamyllynkatu 4-8), FI-20520 Turku, Finland. E-mail: teijo.saari{at}gmail.com
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Pharmacological Reviews: 63 (1)
Pharmacological Reviews
Vol. 63, Issue 1
1 Mar 2011
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Review ArticleReview Article

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Teijo I. Saari, Mikko Uusi-Oukari, Jouni Ahonen and Klaus T. Olkkola
Pharmacological Reviews March 1, 2011, 63 (1) 243-267; DOI: https://doi.org/10.1124/pr.110.002717

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Review ArticleReview Article

Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology

Teijo I. Saari, Mikko Uusi-Oukari, Jouni Ahonen and Klaus T. Olkkola
Pharmacological Reviews March 1, 2011, 63 (1) 243-267; DOI: https://doi.org/10.1124/pr.110.002717
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  • Article
    • Abstract
    • I. Introduction
    • II. GABAA Receptors
    • III. Benzodiazepines
    • IV. Clinical Use of Benzodiazepines in Anesthesiology
    • V. GABAAR Subtypes As a Specific Target for New Sedatives and Hypnotics
    • Authorship Contributions
    • Acknowledgments
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    • References
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