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Review ArticleReview Article

Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Anita E. Autry and Lisa M. Monteggia
Lynette C. Daws, ASSOCIATE EDITOR
Pharmacological Reviews April 2012, 64 (2) 238-258; DOI: https://doi.org/10.1124/pr.111.005108
Anita E. Autry
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas
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Lisa M. Monteggia
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas
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Lynette C. Daws
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas
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Abstract

Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the involvement of this ubiquitous growth factor in major depressive disorder, schizophrenia, addiction, Rett syndrome, as well as other psychiatric and neurodevelopmental diseases. In addition, the review includes a discussion of the role of BDNF in the mechanism of action of pharmacological therapies currently used to treat these diseases, such antidepressants and antipsychotics. The review also covers a critique of experimental therapies such as BDNF mimetics and discusses the value of BDNF as a target for future drug development.

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  • This article is available online at http://pharmrev.aspetjournals.org.

    http://dx.doi.org/10.1124/pr.111.005108.

  • © 2012 by The American Society for Pharmacology and Experimental Therapeutics
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Pharmacological Reviews: 64 (2)
Pharmacological Reviews
Vol. 64, Issue 2
1 Apr 2012
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Review ArticleReview Article

BDNF AND NEUROPSYCHIATRIC DISORDERS

Anita E. Autry and Lisa M. Monteggia
Pharmacological Reviews April 1, 2012, 64 (2) 238-258; DOI: https://doi.org/10.1124/pr.111.005108

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Review ArticleReview Article

BDNF AND NEUROPSYCHIATRIC DISORDERS

Anita E. Autry and Lisa M. Monteggia
Pharmacological Reviews April 1, 2012, 64 (2) 238-258; DOI: https://doi.org/10.1124/pr.111.005108
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  • Article
    • Abstract
    • I. Introduction
    • II. Major Depressive Disorder and Therapies
    • III. Brain-Derived Neurotrophic Factor and Other Mood-Related Disorders
    • IV. Schizophrenia
    • V. Addiction
    • VI. Neurodevelopmental Disorders
    • VII. Brain-Derived Neurotrophic Factor and Eating Disorders
    • VIII. Brain-Derived Neurotrophic Factor-Based Therapeutics
    • IX. Conclusions and Future Directions
    • Acknowledgments
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