Review ArticleReview Article
Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes
Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall and Michael M. Gottesman
David R. Sibley, ASSOCIATE EDITOR
Pharmacological Reviews July 2012, 64 (3) 706-721; DOI: https://doi.org/10.1124/pr.111.005637
Ding-Wu Shen
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Lynn M. Pouliot
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Matthew D. Hall
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Michael M. Gottesman
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
David R. Sibley
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
CANCER CELL RESISTANCE TO CISPLATIN
Ding-Wu Shen, Lynn M. Pouliot, Matthew D. Hall and Michael M. Gottesman
Pharmacological Reviews July 1, 2012, 64 (3) 706-721; DOI: https://doi.org/10.1124/pr.111.005637
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- Article
- Abstract
- I. Introduction: The Complexities of Cisplatin Sensitivity and Resistance
- II. Basic Features
- III. Membrane Transporters and Cisplatin Resistance
- IV. Endocytosis and Cisplatin Resistance
- V. Countering Cisplatin Toxicity: Heat Shock Proteins, GTPases, Ribosomal Proteins
- VI. Epigenetic Changes in Cisplatin Resistance: Chromatin, DNA-Methylation, Histones
- VII. Transcription Factors Affecting Cisplatin Sensitivity
- VIII. Epithelial to Mesenchymal Transition, Wingless Gene, and Protein Kinase B Differentiation Pathways
- IX. MicroRNA Involvement
- X. DNA Repair and BRCA Mutant Genes in Cisplatin Resistance
- XI. Conclusions
- Acknowledgments
- Authorship Contributions
- Footnotes
- References
- Figures & Data
- Info & Metrics
- eLetters
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