Clinical Pharmacology Unit, University of Cambridge, Cambridge, United Kingdom (A.P.D.); School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, United Kingdom (S.P.H.A.); The University/BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom (J.L.S., A.J.P., H.E.B., A.E.M., W.C.L., C.P.M., A.J.H.); Section on Functional Neuroscience, National Institute of Mental Health, Bethesda, Maryland (T.I.B.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (R.R.N.); Department of Molecular Pharmacology, Institute of Functional Genomics, CNRS UMR5203, Universities Montpellier, Montpellier, France (J.P.P.); and Les Laboratoires Servier, Suresnes, France (M.S.)