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Open Access
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior
Fulton T. Crews, Ryan P. Vetreno, Margaret A. Broadwater and Donita L. Robinson
Leslie A. Morrow, ASSOCIATE EDITOR
Pharmacological Reviews October 2016, 68 (4) 1074-1109; DOI: https://doi.org/10.1124/pr.115.012138
Fulton T. Crews
Bowles Center for Alcohol Studies (F.T.C., R.P.V., M.A.B., D.L.R.), Department of Psychiatry (F.T.C., D.L.R.), and Department of Pharmacology (F.T.C.), School of Medicine, University of North Carolina, Chapel Hill, North Carolina
Ryan P. Vetreno
Bowles Center for Alcohol Studies (F.T.C., R.P.V., M.A.B., D.L.R.), Department of Psychiatry (F.T.C., D.L.R.), and Department of Pharmacology (F.T.C.), School of Medicine, University of North Carolina, Chapel Hill, North Carolina
Margaret A. Broadwater
Bowles Center for Alcohol Studies (F.T.C., R.P.V., M.A.B., D.L.R.), Department of Psychiatry (F.T.C., D.L.R.), and Department of Pharmacology (F.T.C.), School of Medicine, University of North Carolina, Chapel Hill, North Carolina
Donita L. Robinson
Bowles Center for Alcohol Studies (F.T.C., R.P.V., M.A.B., D.L.R.), Department of Psychiatry (F.T.C., D.L.R.), and Department of Pharmacology (F.T.C.), School of Medicine, University of North Carolina, Chapel Hill, North Carolina
Leslie A. Morrow
Bowles Center for Alcohol Studies (F.T.C., R.P.V., M.A.B., D.L.R.), Department of Psychiatry (F.T.C., D.L.R.), and Department of Pharmacology (F.T.C.), School of Medicine, University of North Carolina, Chapel Hill, North Carolina
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Adolescent Alcohol Impacts Adult
Fulton T. Crews, Ryan P. Vetreno, Margaret A. Broadwater and Donita L. Robinson
Pharmacological Reviews October 1, 2016, 68 (4) 1074-1109; DOI: https://doi.org/10.1124/pr.115.012138
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- Article
- Visual Overview
- Abstract
- I. Introduction
- II. Brain Maturation and Adolescence
- III. Adolescent Alcohol Sensitivity
- IV. Adolescents Binge Drink
- V. Modeling Adolescent Alcohol Drinking
- VI. Lock-In—Persistence of an Adolescent Phenotype in Adulthood, Including an Adolescent-Typical Response to Ethanol
- VII. AIE Increases Ethanol Self-Administration in Adulthood
- VIII. AIE Results in Decreased Behavioral Flexibility
- IX. Adolescent Alcohol Effects on Anxiety and Negative Affective Behavior
- X. Adolescent Alcohol-Induced Neuroimmune Gene Induction
- XI. Brain Electroencephalography and Sleep
- XII. Cholinergic System Development and Effects of AIE
- XIII. Monoamine System Development and Effects of AIE
- XIV. Hippocampal Development and Effects of AIE
- XV. Adolescent Alcohol-Induced Epigenetic Alterations in Gene Expression
- XVI. Conclusions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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