Review ArticleReview Article
Target Site Delivery and Residence of Nanomedicines: Application of Quantitative Systems Pharmacology
Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu
Yoshihiro Ishikawa, ASSOCIATE EDITOR
Pharmacological Reviews April 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816
Jessie L.-S. Au
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
Roberto A. Abbiati
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
M. Guillaume Wientjes
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
Ze Lu
Institute of Quantitative Systems Pharmacology, Carlsbad, California (J.L.-S.A., R.A.A., M.G.W., Z.L.); Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma (J.L.-S.A., R.A.A.); Optimum Therapeutics LLC, Carlsbad, California (J.L.-S.A., M.G.W., Z.L.); and College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Republic of China (J.L.-S.A.)
Yoshihiro Ishikawa
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
QSP to Evaluate Target Site Delivery of Nanomedicines
Jessie L.-S. Au, Roberto A. Abbiati, M. Guillaume Wientjes and Ze Lu
Pharmacological Reviews April 1, 2019, 71 (2) 157-169; DOI: https://doi.org/10.1124/pr.118.016816
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- Article
- Abstract
- I. Introduction
- II. Transport from Blood to the Tissue Interstitium
- III. Interactions with the Extracellular Matrix and Cells
- IV. Intracellular Trafficking
- V. Examples of Applying Quantitative Systems Pharmacology to Estimate the Target Site Delivery and Residence of Small Molecule Drugs and Nanosized Medicines
- VI. Interaction of Nanosized Medicine and Proteins to Form Protein Corona
- VII. Unique Regulatory Issues Regarding Nanosized Medicine Products
- VIII. Conclusions and Perspectives
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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