Review ArticleReview Article
Brothers in Arms: ABCA1- and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment
Sanne J. C. M. Frambach, Ria de Haas, Jan A. M. Smeitink, Gerard A. Rongen, Frans G. M. Russel and Tom J. J. Schirris
Martin C. Michel, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 152-190; DOI: https://doi.org/10.1124/pr.119.017897
Sanne J. C. M. Frambach
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Ria de Haas
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Jan A. M. Smeitink
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Gerard A. Rongen
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Frans G. M. Russel
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Tom J. J. Schirris
Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences (S.J.C.M.F., G.A.R., F.G.M.R., T.J.J.S.), Radboud Center for Mitochondrial Medicine (S.J.C.M.F., R.d.H., J.A.M.S., F.G.M.R., T.J.J.S.), Department of Pediatrics (R.d.H., J.A.M.S.), and Department of Internal Medicine, Radboud Institute for Health Sciences (G.A.R.), Radboud University Medical Center, Nijmegen, The Netherlands
Martin C. Michel
Roles: ASSOCIATE EDITOR
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In this issue
Review ArticleReview Article
Increased Cholesterol Efflux To Treat Cardiovascular Disease
Sanne J. C. M. Frambach, Ria de Haas, Jan A. M. Smeitink, Gerard A. Rongen, Frans G. M. Russel and Tom J. J. Schirris
Pharmacological Reviews January 1, 2020, 72 (1) 152-190; DOI: https://doi.org/10.1124/pr.119.017897
Review ArticleReview Article
Increased Cholesterol Efflux To Treat Cardiovascular Disease
Sanne J. C. M. Frambach, Ria de Haas, Jan A. M. Smeitink, Gerard A. Rongen, Frans G. M. Russel and Tom J. J. Schirris
Pharmacological Reviews January 1, 2020, 72 (1) 152-190; DOI: https://doi.org/10.1124/pr.119.017897
Jump to section
- Article
- Visual Overview
- Abstract
- I. Introduction
- II. Reverse Cholesterol Transport Pathway
- III. Apolipoprotein A-I and Apolipoprotein E Mimetics
- IV. Regulation and Pharmacological Manipulation of Nuclear Receptor–Mediated ATP-Binding Cassette A1 and ATP-Binding Cassette G1 Expression
- V. ATP-Binding Cassette A1 and ATP-Binding Cassette G1 mRNA Stability
- VI. ATP-Binding Cassette A1 and ATP-Binding Cassette G1 Protein Degradation as a Target to Increase Cholesterol Efflux
- VII. ATP-Binding Cassette A1 Function and Cyclic Adenosine Monophosphate
- VIII. Increasing Cellular Cholesterol Efflux via Unknown Mechanisms
- IX. Conclusions and Future Directions
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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