Review ArticleReview Article
Organic Cation Transporters in Health and Disease
Hermann Koepsell
Lynette C. Daws, ASSOCIATE EDITOR
Pharmacological Reviews January 2020, 72 (1) 253-319; DOI: https://doi.org/10.1124/pr.118.015578
Hermann Koepsell
Institute of Anatomy and Cell Biology and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany
Lynette C. Daws
Roles: ASSOCIATE EDITOR
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Review ArticleReview Article
Organic Cation Transporters
Hermann Koepsell
Pharmacological Reviews January 1, 2020, 72 (1) 253-319; DOI: https://doi.org/10.1124/pr.118.015578
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- Article
- Abstract
- I. Introduction
- II. Cloning, Chromosomal Location, Functional Properties, and Regulation of Human Organic Cation Transporters
- III. Structure–Function Relationships in Organic Cation Transporters
- IV. Expression and Locations of Human Organic Cation Transporters in Cells, Tissues, Organs, and Tumors
- V. Model Substrates and Endogenous Compounds That Are Transported by Human Organic Cation Transporters
- VI. Toxins That Are Transported by Human Organic Cation Transporters
- VII. Drugs That Are Substrates and/or Inhibitors of Human Organic Cation Transporters
- VIII. Genetic Variants in Human Organic Cation Transporters
- IX. Effects of Genetic Variants in Organic Cation Transporters on Drug Treatment
- X. Drug–Drug Interactions of Substrates and Inhibitors at Organic Cation Transporters
- XI. Diseases That Are Associated with Genetic Variants in Organic Cation Transporters
- XII. Insights in Potential Physiologic and Biomedical Functions of Human Organic Cation Transporters from Animal Experiments
- XIII. In Vitro Drug Testing
- XIV. Concluding Remarks
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
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