1 (1962–1966) | I | Pred, VCR | None | MTX or 6-MP, CYCLO, VCR | CSI | None |
II |
III | Pred, VCR | None | MTX, 6-MP, CYCLO, VCR | CSI | None |
IV | Pred, VCR | MTX, 6-MP, CYCLO | MTX, 6-MP CYCLO, VCR full- vs. half-dosage | None | None |
2 (1967–1979) | V | Pred, VCR | MTX, 6-MP, CYCLO | MTX, 6-MP, CYCLO | CSI | Pred, VCR |
VI | Pred, VCR, DNR | MTX, 6-MP, CYCLO vs. none | MTX, 6-MP, CYCLO, Pred, VCR | CSI vs. none | None |
VII | Pred, VCR | None | MTX, 6-MP, CYCLO (+Pred, VCR) | CSI, MTX vs. CSI | None |
VIII | Pred, VCR, ASNase | None | Four groups | CSI, MTX | None |
1. MTX |
2. MTX, 6-MP |
3. MTX, 6-MP, CYCLO |
4. MTX, 6-MP, CYCLO, ara-C |
IX | Three groups | | MTX, 6-MP | CSI, MTX | None |
1. Pred, VCR, DNR | 1. None |
2. Pred, VCR, DNR, ASNase | 2. None |
3. Pred, VCR, DNR | 3. ASNase, Ara-C |
3 (1979–1983) | X | Pred, VCR, ASNase, MTX | None | MTX, 6-MP vs. MTX, 6-MP, CYCLO, Dox, TEN, ara-C | MTX vs. CSI, MTX | None |
4 (1984–1991) | XI | Pred, VCR, DNR, ASNase, TEN, Ara-C | MTX | EP, CYCLO, MTX, 6-MP, TEN, Ara-C, Pred, VCR | MTX, Hyd, Ara-C (+ cranial irradiation in higher risk) | None |
XII | Pred, VCR, DNR, ASNase, TEN, Ara-C | None | 6-MP, MTX, TEN, Ara-C | MTX, Hyd, Ara-C (+ cranial irradiation in higher risk) | None |
5 (1991–1999) | XIIIA XIIIB | MTX (preinduction), Pred, VCR, DNR, ASNase, EP, Ara-C | MTX, 6-MP | Higher-risk EP, CYCLO, 6-MP, MTX, Ara-C, Dex, VCR | MTX, Hyd, Ara-C (+ cranial irradiation in higher risk) | Pred, VCR, DNR, ASNase, EP, Ara-C, MTX, 6-MP |
Lower-risk ASNase, Dex, or 6-MP, MTX, Pred, and VCR |
XIV | MTX (preinduction), Pred, VCR, DNR, ASNase, Ara-C, EP | MTX, 6-MP | Dex, VCR, MTX, Ara-C, EP, CYCLO, ASNase, 6-MP, idarubicin | MTX, Hyd, Ara-C | Dex, VCR, 6-MP, MTX, Ara-C, ASNase, idarubicin |
6 (2000–2007) | XV | MTX (preinduction), Pred, VCR, DNR, ASNase, Ara-C, CYCLO, 6-MP (Imatinib; Ph-positive) | MTX, 6-MP | Dex, DOX, VCR, 6-MP, ASNase, Ara-C, MTX, CYCLO | MTX, Hyd, Ara-C | Dex, VCR, Dox, Ara-C, ASNase |
7 (2007–) | XVI | Pred, VCR, DNR, ASNase, CYCLO, Ara-C, TG | MTX, 6-MP | Dex, DOX, VCR, 6-MP, ASNase, MTX | MTX, Hyd, Ara-C | Dex, VCR, Dox, Ara-C, ASNase |
XVIIa | Pred, VCR, DNR, ASNase, CYCLO, Ara-C, 6-MP | MTX, 6-MP, Ara-C, VCR, ASNase, CYCLO | Dex, DOX, VCR, 6-MP, ASNase, MTX, CYCLO, Ara-C | MTX, Hyd, Ara-C | Dex, VCR, Dox, Ara-C, ASNase |