Biochemical and Biophysical Research Communications
Regular ArticleOrexins Suppress Catecholamine Synthesis and Secretion in Cultured PC12 Cells
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OX2R activation induces PKC-mediated ERK and CREB phosphorylation
2012, Experimental Cell ResearchCitation Excerpt :Orexins had different effects on cAMP in different type of sources. Orexins may not stimulate cAMP accumulation [34] or inhibit the PACAP-induced increase in the cAMP level in PC12 cells [37]. Conversely, orexin significantly increased the cAMP level in human adrencortical cells [38].
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
2010, Frontiers in NeuroendocrinologyReinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells
2008, Neuroscience LettersRole of PACAP in the physiology and pathology of the sympathoadrenal system
2008, Frontiers in NeuroendocrinologyCitation Excerpt :PACAP stimulates the gene transcription of catecholamine biosynthetic enzymes in PC12 cells. The neuropeptide activates PAC1 receptors to increase TH gene transcription through a PKA-controlled pathway [18,19,101], and induces PNMT gene expression through activation of cAMP-PKA and extracellular Ca2+ signaling mechanisms [170]. In addition, PACAP regulates the gene transcription of chromogranins; the peptide enhances CgA and CgB gene expression [44,86,144], and inhibits SgII gene expression [44].
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