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Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior

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Summary

Intracerebral infusion of (+) bicuculline methiodide, but not of its (−) isomer, in the preoptic area, stimulated masculine sexual behavior in rat as evidenced by a decrease in the number of intromissions preceding ejaculation and a shortening of the ejaculation latency and postejaculatory interval. Data suggest a role of the GABAergic system in mediating masculine sexual behavior.

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Acknowledgments. Authors wish to thank Ms Elisabeth Wallin for excellent technical assistance and Ms Madelene Kröning for preparing the figures.

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Fernández-Guasti, A., Larsson, K. & Beyer, C. Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior. Experientia 41, 1414–1416 (1985). https://doi.org/10.1007/BF01950011

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