Paraventricular nucleus lesion prevents yawning and penile erection induced by apomorphine and oxytocin but not by ACTH in rats
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Oxytocinergic neurons, but not oxytocin, are crucial for male penile erection
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2013, Progress in NeurobiologyCitation Excerpt :In line with this hypothesis, the pro-erectile effect of THIQ was partially reduced by L-368899, a non-peptide oxytocin receptor antagonist selected for its ability to prevent oxytocin-induced contraction in uterine membranes, but never tested for its ability to reduce oxytocin-induced penile erection (Martin et al., 2002; Martin and McIntyre, 2004). However, against this possibility are early studies showing that (1) the pro-erectile effect of ACTH given I.C.V. is scarcely influenced by bilateral electrolytic lesions of the PVN (Argiolas et al., 1987a) or by classical oxytocin receptor antagonists given I.C.V. (Argiolas et al., 1987b) in awake freely moving male rats, and (2) the increase in intracavernous pressure induced by I.C.V. α-MSH is not antagonized by a classical oxytocin receptor antagonist in anaesthetised male rats in contrast to that induced by oxytocin (Mizusawa et al., 2002). The discrepancy between these studies is probably only apparent, because the reduction by L-368899 of THIQ-induced penile erection reported in this study is very modest (only 20%) (Martin et al., 2002).
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This work was supported by CNR Grant 85.00605.56.