Progress in Neuro-Psychopharmacology and Biological Psychiatry
Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects
References (22)
- et al.
Improved sexual function in male haemodialysis patients on bromocrip tine
Lancet
(1979) - et al.
Effect of sulpiride, an atypical neuroleptic, on apomorphine-induced growth hormone secretion
Brain Res. Bull.
(1982) - et al.
Penile erection induced by apomorphine and N-n-propyl-norapomorphine in rats
Arch. Int. Pharmacodyn. Ther.
(1979) Pharmacotherapy of sexual impotence in the male
Mod. Probl. Pharmacopsych.
(1980)- et al.
Effect of l-dopa on sexually impotent patients
Psychopharmacologia (Berl.)
(1972) Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence
Brit. J. Psychiat.
(1983)Clinical studies with apomorphine
- et al.
Apomorphine and psychopathology
J. Neurol. Neurosurg. Psychiat.
(1975) - et al.
Effect of methysergide and pimozide on apomorphine-induced growth hormone secretion in men
J. Clin. Endocrinol. Metab.
(1977) - et al.
Effect of naloxone or levallorphan on serum prolactin concentrations and apomorphine-induced growth hormone secretion
Acta Psychiat. Scand.
(1979)
Effect of domperidone on apomorphine-induced growth hormone secretion in normal men
J. Neural Trans.
Cited by (95)
Male Sexual Behavior
2015, Knobil and Neill's Physiology of Reproduction: Two-Volume SetCentral Nervous System Agents and Erectile Dysfunction
2011, Urologic Clinics of North AmericaCitation Excerpt :In one of the earliest clinical reports on the use of apomorphine, Lal and colleagues12 reported reproducible erections in 7 of 9 men injected subcutaneously with varying doses of the drug.
Future sexual medicine physiological treatment targets
2010, Journal of Sexual MedicineCitation Excerpt :Dopamine agonists are perhaps the best known compounds that facilitate penile erection in male mammals, including man. Apomorphine is the best known dopaminergic agonist which is commercially available and labeled for the therapy of ED [33] activates dopamine receptors of the D2 family in order to facilitate penile erection[34–36]. Molecular biology studies have shown that D2 receptors may be divided into D2 (long and short variants), D3, and D4 receptor subtypes [37].
Pathways of sexual desire
2009, Journal of Sexual MedicineCitation Excerpt :It is now generally acknowledged that DA agonists stimulate sexual excitement and arousal in both rats and humans, especially in circumstances where the expression of these appetitive behaviors is endogenously low. Although the general DA receptor agonist apomorphine stimulates penile erection in normally functioning male rats and men with erectile dysfunction [79,80], it has not been reported to affect measures of sexual desire in normally functional rats. However, the D2-selective agonist quinelorane activated copulation in sexually inactive male rats and reduced the ejaculatory threshold in males who copulated [81].
Ginkgo biloba extract enhances male copulatory behavior and reduces serum prolactin levels in rats
2008, Hormones and BehaviorEffects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male rat
2007, European Journal of Pharmacology