Apomorphine-induced penile tumescence in impotent patients — preliminary findings

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Abstract

  • 1.

    1. Apomorphine (Apo), a short acting dopamlne (DA) receptor agonist induces penile erections in normal subjects. The erectile response to one or more doses of Apo HC1 (0.25, 0.5, 0.75, 1.0 mg sc) or placebo was investigated in eight impotent subjects and penile tumescence monitored using a mercury strain gauge and strip chart recording.

  • 2.

    2. Four patients showed a full erection with Apo and one a partial response. Distressing side effects (nausea, sweating) were associated with non-response or partial response.

  • 3.

    3. Three responders to Apo were treated with low doses of the long acting DA receptor agonist, bromocriptine (2.5–3.75 mg/d po); all three showed complete recovery of erectile function within two weeks.

  • 4.

    4. A subgroup of impotent patients may have impaired central DA function. Testing with Apo may provide a diagnostic and predictive test to identify such patients who may respond to treatment with low doses of bromocriptine or other DA receptor agonist.

References (43)

  • O. Benkert

    Pharaacotherapy of sexual impotence in the male

    Mod. Probl. Pharmacopsych.

    (1980)
  • M.B. Bowers et al.

    Sexual behaviour during L-dopa treatment for Parkinsonism

    Am.J. Psychiat.

    (1971)
  • G.S. Brindley

    Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence

    Brit. J. Psychiat.

    (1983)
  • E. Brown et al.

    Sexual function and effect in Parkinsonian men treated with L-dopa

    Am. J. Psychiat.

    (1978)
  • J. Buvat et al.

    La prolactinémie dans 845 cas de dysfunctions sexuelles cliniquement idiopathiques

    Nouv. Presse Med.

    (1982)
  • J.N. Carter et al.

    Prolactin secreting tumours and hypogonadism in 22 men

    New Engl. J. Med.

    (1978)
  • W.E. Collins et al.

    Multidisciplinary survey of erectile impotence

    Canad. Med. Assoc. J.

    (1987)
  • S. Frank et al.

    Prevalence and presentation of hyperprolactinemia in patients with functional pituitary tumors

    Lancet

    (1977)
  • M. Hyppa et al.

    The activating effect of L-dopa treatment on sexual functions and its experimental background

    Acta Neurol. Scand. Suppl.

    (1970)
  • H.S. Kaplan

    The new sex therapy: active treatment of dysfunctions

    (1974)
  • I. Karacan et al.

    Nocturnal erections, differential diagnosis of impotence and diabetes

    Biol. Psychiat.

    (1977)
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