Nitric oxide-synthesizing neurons originating at several different levels innervate rat penis
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Cited by (27)
Phoneutria nigriventer spider toxin Tx2-6 induces priapism in mice even after cavernosal denervation
2017, ToxiconCitation Excerpt :According to this review, the relative contribution of nNOS and eNOS to the erectile process was not completely determined. As discussed by Mizusawa and col. (Mizusawa et al., 2001), the NADPH-Diaphorase-positive (NOS) nerve labelling in rat cavernosal tissue seems restricted to the penile arteries (Schirar et al., 1994; Vanhatalo et al., 1996) though not exclusively (Keast, 1992). However, according to his own results in mice, vesicular ACh transporter- and NOS-immunoreactivity overlap in cavernosal smooth muscle bundles, suggesting an important role for NOS in the mouse cavernous tissue.
Nitric oxide synthase inhibition ameliorates nicotine-induced sperm function decline in male rats
2015, Asian Pacific Journal of ReproductionCitation Excerpt :NO was first recognized in the reproductive system by Ignarro et al. [3], who demonstrated that NO was generated in response to non-adrenergic/non-cholinergic neurotransmission-mediated penile erection. Following this finding, several other studies have implicated NO in its involvement in penile erection at several neuronal levels [4]. It has long been documented that regulation of penile erection by androgens and the pituitary and its relationship with NOS activity is of special physiological interest and deficiency of male sex hormone such as testosterone, has long been associated with impotence and dysfunction of penile erection [5,6].
Changes of NADPH-diaphorase reactivity in lumbar spinal cord of short-term streptozotocin induced diabetic rats
2004, Brain ResearchCitation Excerpt :Evidences of the colocalization of NADPH-d reactivity and NOS immunoreactivity have been described, justifying the use of the first technique to characterize NO-producing neurons in lumbar spinal cord [7,12]. Most (76%) of the penis-projecting neurons in the major pelvic ganglion exhibited NADPH-d activity [41]. NOS immunoreactivity was intense in neurons of layers I–IV and layer X throughout the entire spinal cord, in the preganglionic autonomic neurons of the intermediolateral cell column (ILCC), in the thoracic and lumbar spinal cord and surrounding some large motor neurons in the ventral horns [31].
No colocalization of immunoreactivities for VIP and neuronal NOS, and a differential relation to cGMP-immunoreactivity in bovine penile smooth muscle
2000, Journal of Chemical NeuroanatomyChapter VIII The nitric oxide system in the urogenital tract
2000, Handbook of Chemical NeuroanatomyChapter VII Nitric oxide in the peripheral autonomic nervous system
2000, Handbook of Chemical Neuroanatomy