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Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus

Abstract

The neuropeptide oxytocin, synthesized by magnocellular neurones in the hypothalamus, is well known for its peripheral action during lactation and parturition after its release into the bloodstream from axons in the neurohypophysis. However, it may also be released centrally to control the activity of oxytocinergic neurones themselves. Oxytocin release has been measured from isolated magnocellular nuclei in vitro1 and in the cerebrospinal fluid2,3. When injected into the third ventricle, the peptide increases the basal firing rate of oxytocinergic neurones as well as the frequency and amplitude of the bursts of action potentials they normally show before each reflex milk ejection4,5. Oxytocin also excites magnocellular neurones when applied microiontophoretically6. I now report that immunocytochemical staining reveals synapses in the supraoptic nucleus of the hypothalamus where both the pre-and postsynaptic elements contain oxytocin. These oxytocinergic synapses, impinging on their own neurones, may represent the anatomical basis for the hypothalamic release of this peptide and for the facilitatory action on its own secretion.

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References

  1. Moos, F. et al. J. Endocr. 102, 63–72 (1984).

    Article  CAS  Google Scholar 

  2. Jones, P. M., Robinson, I. C. A. F. & Harris, M. C. Neuroendocrinology 37, 454–458 (1983).

    Article  CAS  Google Scholar 

  3. Robinson, I. C. A. F. & Jones, P. M. Neuroendocrinology 34, 60 & 64 (1982).

    Article  CAS  Google Scholar 

  4. Freund-Mercier, M. J. & Richard, P. Neurosci. Lett. 23, 193 & 198 (1981).

    Article  CAS  Google Scholar 

  5. Freund-Mercier, M. J. & Richard, Ph. J. Physiol., Land. 352, 447 & 466 (1984).

    Article  CAS  Google Scholar 

  6. Moss, R. L., Dyball, R. E. J. & Cross, B. A. Expl Neurol. 34, 95 & 102 (1972).

    Article  CAS  Google Scholar 

  7. Sternberger, L. A. Immunocytochemistry (Prentice-Hall, Englewood Cliffs, New Jersey, 1974).

  8. Theodosis, D. T. & Poulain, D. A. Cell Tissue Res. 235, 217 & 219 (1984).

    Article  CAS  Google Scholar 

  9. Burlet, A., Tonon, M. C., Tankosic, P., Coy, D. & Vaudry, H. Neuroendocrinology 37, 64 & 72 (1983).

    Article  CAS  Google Scholar 

  10. Theodosis, D. T. Brain Res. 233, 3 & 16 (1982).

    Article  CAS  Google Scholar 

  11. Buijs, R. M. & Swaab, D. F. Cell Tissue Res. 204, 355 & 365 (1979).

    Article  CAS  Google Scholar 

  12. Poulain, D. A. & Wakerley, J. Neuroscience 7, 773 & 808 (1982).

    Article  CAS  Google Scholar 

  13. Mason, W. T., Ho, Y. W. & Hatton, G. I. Neuroscience 11, 169 & 182 (1984).

    Article  CAS  Google Scholar 

  14. Silverman, A. J., Hoffman, D. L. & Zimmerman, E. A. Brain Res. Bull. 6, 47 & 61 (1981).

    Article  CAS  Google Scholar 

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Theodosis, D. Oxytocin-immunoreactive terminals synapse on oxytocin neurones in the supraoptic nucleus. Nature 313, 682–684 (1985). https://doi.org/10.1038/313682a0

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