Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Regular ArticleThe role of prostaglandins in the aetiology and treatment of erectile dysfunction
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Cited by (41)
Effects of evening primrose oil capsules on the sexual function of reproductive-aged women: A randomized clinical trial study
2022, SexologiesCitation Excerpt :Prostaglandin E1 is used in the treatment of male erectile dysfunction as a suppository or as an intra-tissue injection (Urciuoli et al., 2004). Prostaglandins enhance the penetrability of blood vessels and act as a vasodilator (Khan et al., 1999). Prostaglandins in women also stimulate the uterus, and prostaglandin E leads to the contraction of proximal part of the fallopian tubes (a quarter of the length of the tube that is closest to the uterine body) (Karim and Hillier, 1974), which can increase experienced orgasm because of improved uterine and fallopian tube contractions (Traish et al., 2004).
Pharmacology and perspectives in erectile dysfunction in man
2020, Pharmacology and TherapeuticsCitation Excerpt :Prostanoids are a heterogeneous group of substances with different physiological effects on the body. Penile erectile tissue is able to locally synthesize and metabolize most of these substances (Jeremy, Morgan, Mikhailidis, & Dandona, 1986; Khan et al., 1999; Minhas, Cartledge, & Eardley, 2000; Moreland et al., 2001). Production of thromboxane A2 (TXA2), prostaglandin F2α (PGF2α), prostacyclin (PGI2), prostaglandin D2 (PGD2), and prostaglandin E2 (PGE2) has been reported in HCC.
Amiloride Relaxes Rat Corpus Cavernosum Relaxation In Vitro and Increases Intracavernous Pressure In Vivo
2019, Journal of Sexual MedicineEvaluation of some prostaglandins modulators on rat corpus cavernosum in-vitro: Is relaxation negatively affected by COX-inhibitors?
2019, Biomedicine and PharmacotherapyCitation Excerpt :Some of them are involved in contraction of penile tissue including PGF2α and more importantly TXA2 which in turn result in inhibition of penile erection. Others are involved in relaxation such as PGE1 and PGE2 which in turn cause stimulation of penile erection [15]. In this regard, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with erectile dysfunction has been always questionable as they inhibit the COX enzymes and in turn inhibit the synthesis of PGs. Determining the potential effect of COX inhibitors with varying selectivities on corpus cavernosal relaxation may help to reduce the incidence of NSAIDs untoward effects and help prescribing the appropriate COX inhibitor as anti-inflammatory agent for patients with erectile dysfunction.
Steroid Hormones and Other Lipid Molecules Involved in Human Reproduction
2019, Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth EditionProstaglandins and Other Lipid Mediators in Reproductive Medicine
2013, Yen and Jaffe's Reproductive Endocrinology: Seventh Edition