Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Original ArticleThe role of prostaglandins in penile erection
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Cited by (17)
Pharmacology and perspectives in erectile dysfunction in man
2020, Pharmacology and TherapeuticsCitation Excerpt :Prostanoids are a heterogeneous group of substances with different physiological effects on the body. Penile erectile tissue is able to locally synthesize and metabolize most of these substances (Jeremy, Morgan, Mikhailidis, & Dandona, 1986; Khan et al., 1999; Minhas, Cartledge, & Eardley, 2000; Moreland et al., 2001). Production of thromboxane A2 (TXA2), prostaglandin F2α (PGF2α), prostacyclin (PGI2), prostaglandin D2 (PGD2), and prostaglandin E2 (PGE2) has been reported in HCC.
Future sexual medicine physiological treatment targets
2010, Journal of Sexual MedicineCitation Excerpt :cDNAs encoding representatives of each of these groups of receptors have been cloned, including several subtypes of EP receptors. Penile tissues may contain most of these groups of receptors; however, their role in penile physiology is still far from being established [126–128]. Prostanoids may be involved in contraction of erectile tissues via PGF2α and TXA2, stimulating thromboxane (TX) and FP receptors and initiating phosphoinositide turnover, as well as in relaxation via PGE1 and PGE2, stimulating EP receptors (EP2/EP4) and initiating an increase in the intracellular concentration of cAMP [129–131].
Pharmacology of erectile dysfunction in man
2006, Pharmacology and TherapeuticsRegular use of ibuprofen reduces rat penile prostaglandins and induces cavernosal fibrosis
2022, Drug and Chemical ToxicologyErectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?
2021, Sexual DevelopmentAssociation between male use of pain medication and fecundability
2020, American Journal of Epidemiology