Original Article
The role of prostaglandins in penile erection

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References (57)

  • J.T Daley et al.

    Prostanoid production in rabbit corpus cavernosum. II Inhibition by oxidative stress

    J Urol

    (1996)
  • J.T Daley et al.

    Prostanoid production in rabbit corpus cavernosum I. Regulation by oxygen tension

    J Urol

    (1996)
  • H Hedlund et al.

    Contraction and relaxation induced by some prostanoids in isolated human erectile penile tissue and cavernous artery

    J Urol

    (1985)
  • H Hedlund et al.

    Characterization of contraction mediating prostanoid receptors in human penile erectile tissues

    J Urol

    (1989)
  • M.A Khan et al.

    The role of prostaglandins in the aetiology and treatment of erectile dysfunction

    Prostagl Leukotr Essente Fatty Acids

    (1999)
  • K.M Azadzoi et al.

    Diabetes Meliitus impairs neurogenic and endothelium dependant relaxation of rabbit corpus cavernosum smooth muscle

    J Urol

    (1992)
  • M.A Cruz et al.

    Endothelial modulation of vascular tone and 5-hydroxytrptamine induced responses in human chorionic arteries and veins

    Gen Pharmacol

    (1995)
  • H Hedlund et al.

    Comparison of the responses to drugs acting on adrenoreceptors and muscarinic receptors in human isolated corpus cavernosum and cavernous artery

    J Auton Pharmacol

    (1985)
  • I Saen de Tejada et al.

    Regulation of adrenergic activity in penile corpus cavernosum

    J Urol

    (1989)
  • R.M Levin et al.

    Adrenergic alpha receptors outnumber beta receptors in the human penile corpus cavernosum

    Investigative Urol

    (1980)
  • M Shirai et al.

    Histochemical investigation on the distribution of adrenergic and cholinergic nerves in the human penis

    Tohoku J Exp Med

    (1980)
  • J McConnell et al.

    Autonomic innervation of the mammalian penis: a histochemical and physiological study

    J Neural Trans

    (1979)
  • F Holmquist et al.

    Characterisation of inhibitory neurotransmission in the isolated corpus cavernosum from rabbit and man

    J Physiol

    (1992)
  • R.M.J Palmer et al.

    Vascular endothelial cells synthesise nitric oxide from L-arginine

    Nature

    (1988)
  • N Kim et al.

    A nitric oxide like factor mediates NANC relaxation of penile corpus cavernosum smooth muscle

    J Clim Invest

    (1991)
  • K Andrea et al.

    Identification of thirteen phosphodiesterase isoforms in the human cavernous tissue

    Eur Urol

    (1999)
  • R Crowe et al.

    Vasoactive intestinal polypeptide like immunoreactive nerves in diabetic penis. a comparison between streptozotocin treated rats and men

    Diabetes

    (1984)
  • K.E Andersson et al.

    Physiology of penile erection

    Physiol Rev

    (1995)
  • Cited by (17)

    • Pharmacology and perspectives in erectile dysfunction in man

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      Prostanoids are a heterogeneous group of substances with different physiological effects on the body. Penile erectile tissue is able to locally synthesize and metabolize most of these substances (Jeremy, Morgan, Mikhailidis, & Dandona, 1986; Khan et al., 1999; Minhas, Cartledge, & Eardley, 2000; Moreland et al., 2001). Production of thromboxane A2 (TXA2), prostaglandin F2α (PGF2α), prostacyclin (PGI2), prostaglandin D2 (PGD2), and prostaglandin E2 (PGE2) has been reported in HCC.

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      cDNAs encoding representatives of each of these groups of receptors have been cloned, including several subtypes of EP receptors. Penile tissues may contain most of these groups of receptors; however, their role in penile physiology is still far from being established [126–128]. Prostanoids may be involved in contraction of erectile tissues via PGF2α and TXA2, stimulating thromboxane (TX) and FP receptors and initiating phosphoinositide turnover, as well as in relaxation via PGE1 and PGE2, stimulating EP receptors (EP2/EP4) and initiating an increase in the intracellular concentration of cAMP [129–131].

    • Pharmacology of erectile dysfunction in man

      2006, Pharmacology and Therapeutics
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