Effect of 7-nitroindazole on drug-priming reinstatement of D-methamphetamine-induced conditioned place preference

Eur J Pharmacol. 2002 May 17;443(1-3):205-6. doi: 10.1016/s0014-2999(02)01580-7.

Abstract

The study investigated the role of nitric oxide (NO) in the relapse to drug-seeking behavior induced by D-methamphetamine. After the induction of D-methamphetamine (1 mg/kg) conditioned place preference, the rewarding effect became extinct 6 weeks later. The extinguished place preference was reinstated by D-methamphetamine (0.125 mg/kg) injection, an effect which was attenuated by 7-nitroindazole (12.5 and 25 mg/kg) pretreatment. The results demonstrate that NO is involved in relapse primed by D-methamphetamine injection.

MeSH terms

  • Amphetamine-Related Disorders / psychology*
  • Animals
  • Conditioning, Psychological / drug effects*
  • Homing Behavior / drug effects
  • Indazoles / pharmacology*
  • Male
  • Methamphetamine / administration & dosage
  • Methamphetamine / chemistry
  • Methamphetamine / pharmacology*
  • Nitric Oxide / physiology
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase Type I
  • Rats
  • Rats, Sprague-Dawley
  • Recurrence
  • Stereoisomerism

Substances

  • Indazoles
  • Nitric Oxide
  • Methamphetamine
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I
  • Nos1 protein, rat
  • 7-nitroindazole