RT Journal Article SR Electronic T1 THE METABOLISM OF ADRENALINE JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 1 OP 26 VO 1 IS 1 A1 Z. M. BACQ YR 1949 UL http://pharmrev.aspetjournals.org/content/1/1/1.abstract AB The statement formulated in 1905 by Elliott (5) that "adrenalin disappears in the tissues which it excites" is unquestionable. Review of the literature shows 1) that adrenaline may be excreted unchanged in small amounts by the kidneys and stored in the tissues and red blood cells; 2) that its deamination by amineoxidase in the body is unlikely; 3) that an important fraction is sulfoconjugated; 4) that another important fraction is simultaneously oxidized to indole substance; 5) that adrenochrome and its derivatives have important biochemical and physiological properties, entirely different from those of adrenaline, and deserve further study.