RT Journal Article
SR Electronic
T1 D. THE STIMULATION OF GLUCONEOGENESIS FROM LACTATE BY EPINEPHRINE, GLUCAGON, AND CYCLIC 3',5'-ADENYLATE IN THE PERFUSED RAT LIVER
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 181
OP 188
VO 18
IS 1
A1 J. H. Exton
A1 C. R. Park
YR 1966
UL http://pharmrev.aspetjournals.org/content/18/1/181.abstract
AB 1. Gluconeogenesis from lactate in the perfused liver is stimulated by glucagon and the catecholamines. It is suggested that this effect has physiological significance. 2. The effect of the hormones on gluconeogenesis appears to be mediated by cyclic 3',5'-AMP. 3. The hormones (or cyclic 3',5'-AMP) activate more than one step in the pathway of lactate to glucose. The changes in the concentration of metabolic intermediates induced by the hormones are consistent with activations of phosphopyruvate carboxylase and the hexose phosphate phosphatases.