RT Journal Article
SR Electronic
T1 D. CALCIUM AND THE RELAXANT EFFECT OF ISOPROTERENOL IN THE DEPOLARIZED RAT UTERUS
JF Pharmacological Reviews
JO Pharmacol Rev
FD American Society for Pharmacology and Experimental Therapeutics
SP 495
OP 501
VO 18
IS 1
A1 H. O. Schild
YR 1966
UL http://pharmrev.aspetjournals.org/content/18/1/495.abstract
AB The potassium-depolarized rat uterus is highly sensitive to calcium. It responds to calcium by contraction and to calcium-chelating agents by relaxation. Magnesium antagonizes or potentiates the contractile effect of calcium in different concentrations. Isoproterenol produces relaxation which is antagonized competitively by DCI and nonspecifically by chelating agents. The relaxant effect of isoproterenol in potassium-Ringer deteriorates in time but can be restored by temporary immersion in sodium-Ringer. A hypothesis is discussed according to which relaxation is due to a decrease of free intracellular calcium.