RT Journal Article SR Electronic T1 The characterization and function of human immunoregulatory T lymphocyte subsets. JF Pharmacological Reviews JO Pharmacol Rev FD American Society for Pharmacology and Experimental Therapeutics SP 17 OP 22 VO 34 IS 1 A1 E L Reinherz A1 S F Schlossman YR 1982 UL http://pharmrev.aspetjournals.org/content/34/1/17.abstract AB Functional T lymphocyte subpopulations can be identified in humans by antibodies which detect stable glycoprotein antigens on their surface. Thus, inducer T lymphocytes bear an antigen termed T4 while suppressor T lymphocytes bear an antigen termed T5. Immune homeostasis results from a delicate balance between inducer and suppressor subsets within the T-cell circuit and perturbation in subset dynamics may initiate a wide variety of immunopathological disorders. Here Ellis Reinherz and Stuart Schlossman discuss the present understanding of this circuit, its role in the pathogenesis of a number of diseases, and how the human immune response can be manipulated in an orderly way through modulation of selected T-cell subsets.